Association between bone metabolism regulators and arterial stiffness in type 2 diabetes patients
Sharif, S.; Bots, M. L.; Schalkwijk, C.; Stehouwer, C. D.A.; Visseren, F. L.J.; Westerink, J.; SMART Study Group
(2018) Nutrition, Metabolism and Cardiovascular Diseases, volume 28, issue 12, pp. 1245 - 1252
(Article)
Abstract
Background and Aim: Osteopontin (OPN), osteonectin (ON) and osteocalcin (OC) play an important role in the development of vascular calcifications, but it is unclear whether these bone metabolism regulators contribute to the development of arterial stiffness in type 2 diabetes patients. We therefore aim to determine the relationship between plasma
... read more
concentrations of OPN, ON, OC and arterial stiffness in type 2 diabetes patients. Methods: Cross-sectional study of 1003 type 2 diabetes patients included in the Second Manifestations of ARTerial disease (SMART)-cohort. Generalized linear models were used to evaluate the relation between plasma levels of OPN, ON and OC and arterial stiffness as measured by pulse pressure (PP), ankle-brachial index (ABI) (≥0.9), carotid artery distension and an arterial stiffness summary score. Analyses were adjusted for age, sex, kidney function, diabetes duration and diastolic blood pressure. Higher OPN plasma levels were significantly related to a lower ABI (β-0.013; 95%CI −0.024 to −0.002) and a higher arterial stiffness summary score (OR1.24; 95%CI 1.03–1.49). OPN levels were not related to PP (β 0.59; 95%CI −0.63–1.81) or absolute carotid artery distention (β −7.03; 95%CI −20.00–5.93). ON and OC plasma levels were not related to any of the arterial stiffness measures. Conclusion: Only elevated plasma levels of OPN are associated with increased arterial stiffness in patients with type 2 diabetes as measured by the ankle-brachial index and arterial stiffness summary score. These findings indicate that OPN may be involved in the pathophysiology of arterial stiffness and call for further clinical investigation.
show less
Download/Full Text
The full text of this publication is not available.
Keywords: Arteriall stiffness, Biomarkers, Bone metabolism regulators, Diabetes mellitus type 2, Osteocalcin, Osteonectin, Osteopontin, Medicine (miscellaneous), Endocrinology, Diabetes and Metabolism, Nutrition and Dietetics, Cardiology and Cardiovascular Medicine
ISSN: 0939-4753
Publisher: Elsevier
Note: Funding Information: This research was performed within the framework of CTMM, the Center for Translational Molecular Medicine ( www.ctmm.nl ), project PREDICCt (grant 01C-104), and supported by the Netherlands Heart Foundation, Dutch Diabetes Research Foundation, and Dutch Kidney Foundation. Funding Information: We gratefully acknowledge the contribution of the SMART research nurses; R.van Petersen (data-manager); B.G.F. Dinther (vascular manager) and the participants of the SMART Study Group: A. Algra MD,PhD; Y. van der Graaf, MD,PhD; D.E. Grobbee, MD,PhD; G.E.H.M. Rutten, MD,PhD, Julius Center for Health Sciences and Primary care; F.L.J.Visseren, MD,PhD, Department of Internal Medicine; G.J. de Borst, MD,PhD, Department of Vascular Surgery; L.J. Kappelle, MD,PhD, Department of Neurology; T. Leiner, MD,PhD, Department of Radiology; H.M. Nathoe, MD,PhD, Department of Cardiology and we also gratefully acknowledge M. van de Waarenburg for her technical assistance. Publisher Copyright: © 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University Copyright: Copyright 2019 Elsevier B.V., All rights reserved.
(Peer reviewed)