Use of schizophrenia and bipolar disorder polygenic risk scores to identify psychotic disorders
Calafato, Maria Stella; Thygesen, Johan H.; Ranlund, Siri; Zartaloudi, Eirini; Cahn, Wiepke; Crespo-Facorro, Benedicto; Diez-Revuelta, Alvaro; Di Forti, Marta; Hall, Mei-Hua; Iyegbe, Conrad; Jablensky, Assen; Kahn, Rene; Kalaydjieva, Luba; Kravariti, Eugenia; Lin, Kuang; McDonald, Colm; McIntosh, Andrew M.; McQuillin, Andrew; Picchioni, Marco; Rujescu, Dan; Shaikh, Madiha; Toulopoulou, Timothea; Van Os, Jim; Vassos, Evangelos; Walshe, Muriel; Powell, John; Lewis, Cathryn M.; Murray, Robin M.; Bramon, Elvira
(2018) British Journal of Psychiatry, volume 213, issue 3, pp. 535 - 541
(Article)
Abstract
Background There is increasing evidence for shared genetic susceptibility between schizophrenia and bipolar disorder. Although genetic variants only convey subtle increases in risk individually, their combination into a polygenic risk score constitutes a strong disease predictor.Aims To investigate whether schizophrenia and bipolar disorder polygenic risk scores can distinguish people with
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broadly defined psychosis and their unaffected relatives from controls.Method Using the latest Psychiatric Genomics Consortium data, we calculated schizophrenia and bipolar disorder polygenic risk scores for 1168 people with psychosis, 552 unaffected relatives and 1472 controls.Results Patients with broadly defined psychosis had dramatic increases in schizophrenia and bipolar polygenic risk scores, as did their relatives, albeit to a lesser degree. However, the accuracy of predictive models was modest.Conclusions Although polygenic risk scores are not ready for clinical use, it is hoped that as they are refined they could help towards risk reduction advice and early interventions for psychosis.Declaration of interest R.M.M. has received honoraria for lectures from Janssen, Lundbeck, Lilly, Otsuka and Sunovian.
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Keywords: Bipolar disorder, polygenic, polygenic risk scores, prediction, psychotic disorders, schizophrenia
ISSN: 0007-1250
Publisher: Royal College of Psychiatrists
Note: Publisher Copyright: Copyright © The Royal College of Psychiatrists 2018Â This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited..
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