A state-independent network of depressive, negative and positive symptoms in male patients with schizophrenia spectrum disorders
van Rooijen, Geeske; Isvoranu, Adela Maria; Kruijt, Olle H.; van Borkulo, Claudia D.; Meijer, Carin; Wigman, Johanna T.W.; Ruhé, Henricus G.; de Haan, Lieuwe; Bruggeman, Richard; Cahn, Wiepke; de Haan, Lieuwe; Kahn, René S.; Meijer, Carin; Myin-Germeys, Inez; van Os, Jim; Bartels-Velthuis, Agna A.; Genetic Risk and OUtcome of Psychosis investigators; GROUP Investigators
(2018) Schizophrenia Research, volume 193, pp. 232 - 239
(Article)
Abstract
Depressive symptoms occur frequently in patients with schizophrenia. Several factor analytical studies investigated the associations between positive, negative and depressive symptoms and reported difficulties differentiating between these symptom domains. Here, we argue that a network approach may offer insights into these associations, by exploring interrelations between symptoms. The aims of
... read more
current study were to I) construct a network of positive, negative and depressive symptoms in male patients with schizophrenia to investigate interactions between individual symptoms; II) identify the most central symptoms within this network and III) examine group-level differences in network connectivity between remitted and non–remitted patients. We computed a network of depressive, positive and negative symptoms in a sample of 470 male patients diagnosed with a psychotic disorder. Depressive symptoms were assessed with the Calgary Depression Rating Scale for Schizophrenia, while psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Networks of male patients who fulfilled remission criteria (Andreasen et al., 2005) and non–remitters for psychosis were compared. Our results indicate that depressive symptoms are mostly associated with suicidality and may act as moderator between psychotic symptoms and suicidality. In addition, ‘depressed mood’, ‘observed depression’, ‘poor rapport’, 'stereotyped thinking’ and ‘delusions’ were central symptoms within the network. Finally, although remitted male patients had a similar network structure compared to non-remitters the networks differed significantly in terms of global strength. In conclusion, clinical symptoms of schizophrenia were linked in a stable way, independent of symptomatic remission while the number of connections appears to be dependent on remission status.
show less
Download/Full Text
The full text of this publication is not available.
Keywords: Depressive symptoms, Negative symptoms, Network analysis, Network comparison test, Positive symptoms, Schizophrenia, Psychiatry and Mental health, Biological Psychiatry
ISSN: 0920-9964
Publisher: Elsevier
Note: Funding Information: The infrastructure for the GROUP study is funded through the Geestkracht programme of the Dutch Health Research Council (Zon-Mw, grant number 10-000-1001), and matching funds from participating pharmaceutical companies (Lundbeck, AstraZeneca, Eli Lilly, Janssen Cilag) and universities and mental health care organizations (Amsterdam: Academic Psychiatric Centre of the Academic Medical Center and the mental health institutions: GGZ Ingeest, Arkin, Dijk en Duin, GGZ Rivierduinen, Erasmus Medical Centre, GGZ Noord Holland Noord. Groningen: University Medical Center Groningen and the mental health institutions: Lentis, GGZ Friesland, GGZ Drenthe, Dimence, Mediant, GGNet Warnsveld, Yulius Dordrecht and Parnassia psycho-medical center The Hague. Maastricht: Maastricht University Medical Centre and the mental health institutions: GGZ Eindhoven en De Kempen, GGZ Breburg, GGZ Oost-Brabant, Vincent van Gogh voor Geestelijke Gezondheid, Mondriaan, Virenze riagg, Zuyderland GGZ, MET ggz, Universitair Centrum Sint-Jozef Kortenberg, CAPRI University of Antwerp, PC Ziekeren Sint-Truiden, PZ Sancta Maria Sint-Truiden, GGZ Overpelt, OPZ Rekem. Utrecht: University Medical Center Utrecht and the mental health institutions Altrecht, GGZ Centraal and Delta). Funding Information: JTWW is supported by NWO VENI grant (no 016.156.019 ). HGR is supported by a ZonMW/NWO VENI grant (no 016.126.059 ). Publisher Copyright: © 2017 Elsevier B.V.
(Peer reviewed)