Note: Funding Information: AA-C reports other financial relationships with Mitsubishi-Tanabe Pharma, Chronos Therapeutics, OrionPharma, Cytokinetics Inc, and Treeway, outside the submitted work. OH reports personal fees from Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration journal and grants from Science Foundation Ireland outside the submitted work. LHvdB reports grants from ALS Foundation Netherlands, The Netherlands Organization for Health Research and Development (Vici scheme, SOPHIA, STRENGTH, ALS-CarE project; the latter three of which are funded through the EU Joint Programme–Neurodegenerative Disease Research), and personal fees from Shire, Biogen, Cytokinetics, and Treeway, outside the submitted work. H-JW and TPAD declare no competing interests.