Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer

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Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
 
Severson, Tesa M.; Kim, Yongsoo; Joosten, Stacey E.P.; Schuurman, Karianne; Van Der Groep, Petra; Moelans, Cathy B.; Ter Hoeve, Natalie D.; Manson, Quirine F.; Martens, John W.; Van Deurzen, Carolien H.M.; Barbe, Ellis; Hedenfalk, Ingrid; Bult, Peter; Smit, Vincent T.H.B.M.; Linn, Sabine C.; Van Diest, Paul J.; Wessels, Lodewyk; Zwart, Wilbert
(2018) Nature Communications, volume 9, issue 1
(Article)
Abstract
Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.
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Keywords: General Chemistry, General Biochemistry,Genetics and Molecular Biology, General Physics and Astronomy
DOI: https://doi.org/10.1038/s41467-018-02856-2
ISSN: 2041-1723
Publisher: Nature Publishing Group
Note: Funding Information: We thank all patients who contributed to this study. The authors would like to acknowledge all the members of hospitals that provided tumor material. Wilbert Zwart is supported by the Bas Mulder Award from the Dutch Cancer Society (KWF)/ALpe d’HuZes and a VIDI grant from the Netherlands Organization for Scientific Research (NWO). JWMM received funding through the Cancer Genomics Netherlands from The Netherlands Organization for Scientific research (NWO). The authors would also like to acknowledge the effort and support of The Netherlands Cancer Institute (NKI) Genomics Core Facility. In addition, we would like to acknowledge the NKI Core Facility Molecular Pathology and Biobanking (CFMPB) for supplying Biobank material and lab support, especially Ingrid Hofland for GR IHC optimization. Publisher Copyright: © 2018 The Author(s).
(Peer reviewed)