Computed Tomography Perfusion Derived Blood-Brain Barrier Permeability Does Not Yet Improve Prediction of Hemorrhagic Transformation
Horsch, Alexander D.; Bennink, Edwin; van Seeters, Tom; Kappelle, L. Jaap; van der Graaf, Yolanda; Mali, Willem P.T.M.; de Jong, Hugo W.A.M.; Velthuis, Birgitta K.; Dankbaar, Jan Willem
(2018) Cerebrovascular Diseases, volume 45, issue 1-2, pp. 26 - 32
(Article)
Abstract
Introduction: Hemorrhagic transformation (HT) in acute ischemic stroke can occur as a result of reperfusion treatment. While withholding treatment may be warranted in patients with increased risk of HT, prediction of HT remains difficult. Nonlinear regression analysis can be used to estimate blood-brain barrier permeability (BBBP). The aim of this
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study was to identify a combination of clinical and imaging variables, including BBBP estimations, that can predict HT. Materials and Methods: From the Dutch acute stroke study, 545 patients treated with intravenous recombinant tissue plasminogen activator and/or intra-arterial treatment were selected, with available admission extended computed tomography (CT) perfusion and follow-up imaging. Patient admission treatment characteristics and CT imaging parameters regarding occlusion site, stroke severity, and BBBP were recorded. HT was assessed on day 3 follow-up imaging. The association between potential predictors and HT was analyzed using univariate and multivariate logistic regression. To compare the added value of BBBP, areas under the curve (AUCs) were created from 2 models, with and without BBBP. Results: HT occurred in 57 patients (10%). In univariate analysis, older age (OR 1.03, 95% CI 1.006–1.05), higher admission National Institutes of Health Stroke Scale (NIHSS; OR 1.13, 95% CI 1.08–1.18), higher clot burden (OR 1.28, 95% CI 1.16–1.41), poor collateral score (OR 3.49, 95% CI 1.85–6.58), larger Alberta Stroke Program Early CT Score cerebral blood volume deficit size (OR 1.26, 95% CI 1.14–1.38), and increased BBBP (OR 2.22, 95% CI 1.46–3.37) were associated with HT. In multivariate analysis with age and admission NIHSS, the addition of BBBP did not improve the AUC compared to both independent predictors alone (AUC 0.77, 95% CI 0.71–0.83). Conclusion: BBBP predicts HT but does not improve prediction with age and admission NIHSS.
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Keywords: Brain, Ischemic stroke, Computed tomography, Nonlinear regression permeability, Hemorrhagic transformation, Prediction, Thrombolytic Therapy/adverse effects, Predictive Value of Tests, Prospective Studies, Age Factors, Humans, Middle Aged, Stroke/diagnostic imaging, Male, Intracranial Hemorrhages/chemically induced, Capillary Permeability/drug effects, Netherlands, Time Factors, Fibrinolytic Agents/administration & dosage, Cerebrovascular Circulation/drug effects, Aged, 80 and over, Female, Brain Ischemia/diagnostic imaging, Blood-Brain Barrier/diagnostic imaging, Disability Evaluation, Severity of Illness Index, Risk Assessment, Risk Factors, Perfusion Imaging/methods, Treatment Outcome, Computed Tomography Angiography, Cerebral Angiography/methods, Tissue Plasminogen Activator/administration & dosage, Aged, Infusions, Intravenous, Clinical Neurology, Neurology, Cardiology and Cardiovascular Medicine, Research Support, Non-U.S. Gov't, Multicenter Study, Journal Article
ISSN: 1015-9770
Publisher: S. Karger AG
Note: Funding Information: This study was supported by grants from the Netherlands Heart Foundation (grant numbers 2008 T034 and 2012 T061) and the Nuts Ohra Foundation (grant number 0903-012). Publisher Copyright: © 2018 The Author(s) Published by S. Karger AG, Basel.
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