(S)-UH301, a silent 5-HT(1A) receptor antagonist, enhances plasma cortiocosterone levels in the rat

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(S)-UH301, a silent 5-HT(1A) receptor antagonist, enhances plasma cortiocosterone levels in the rat
 
Groenink, L.; Van Der Gugten, J.; Mos, J.; Maes, R.A.A.; Olivier, B.
(1994) Life Sciences, volume 55, issue 5, pp. 99 - 103
(Article)
Abstract
The putative silent 5-HT(1A) receptor antagonist (S)-UH301 (S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin) dose-dependently enhanced (3 to 10 mg/kg, sc) plasma corticosterone levels in undisturbed rats, an effect shared with 5-HT(1A) receptor agonists. (S)-UH301 did not influence plasma glucose levels. This unexpected finding may be indicative of a partial 5-HT(1A)-receptor agonistic effect of (S)-UH301, or ... read more
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Keywords: (S)-U H301, corticosterone, plasma glucose, S-5-fluoro-8-hydroxy-2-(di-n-propylamino)tetralin, 2 dipropylamino 5 fluoro 8 hydroxytetralin, glucose, partial agonist, serotonin 1A receptor, serotonin agonist, serotonin antagonist, agonist, animal experiment, article, controlled study, corticosterone blood level, glucose blood level, male, nonhuman, rat, subcutaneous drug administration
DOI: https://doi.org/10.1016/0024-3205(94)00654-7
ISSN: 0024-3205
Publisher: Elsevier
(Peer reviewed)
 
 
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