Membrane-bound organelles versus membrane-less compartments and their control of anabolic pathways in Drosophila
Aguilera-Gomez, Angelica; Rabouille, Catherine
(2017) Developmental Biology, volume 428, issue 2, pp. 310 - 317
(Article)
Abstract
Classically, we think of cell compartmentalization as being achieved by membrane-bound organelles. It has nevertheless emerged that membrane-less assemblies also largely contribute to this compartmentalization. Here, we compare the characteristics of both types of compartmentalization in term of maintenance of functional identities. Furthermore, membrane less-compartments are critical for sustaining developmental
... read more
and cell biological events as they control major metabolic pathways. We describe two examples related to this issue in Drosophila, the role of P-bodies in the translational control of gurken in the Drosophila oocyte, and the formation of Sec bodies upon amino-acid starvation in Drosophila cells.
show less
Download/Full Text
Keywords: COPII, Cell compartmentalization, Drosophila, ER exit sites, FMR1, Liquid droplets, Liquid-liquid phase separation, Low complexity sequence, Membrane-bound organelles, Membrane-less compartments, Oocyte, Orb, PARP16, S2 cells, Sec16, Secretory pathway, Stress granule, gurken translation, mRNA, Molecular Biology, Cell Biology, Developmental Biology
ISSN: 0012-1606
Publisher: Academic Press Inc.
Note: Funding Information: We thank our colleagues for many discussions on several aspects of this review, especially from the Davis lab (Oxford, UK) on Drosophila P-bodies, and Bram Herpers (Leiden University, the Netherlands) for the micrograph shown in Fig. 1. The work in the Rabouille lab is funded by NWO (De Nederlandse Organisatie voor Wetenschappelijk Onderzoek) and the KNAW (Koninklijke Nederlandse Akademie van Wetenschappen). Publisher Copyright: © 2017 The Authors
(Peer reviewed)