A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease

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A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
 
Keren-Shaul, Hadas; Spinrad, Amit; Weiner, Assaf; Matcovitch-Natan, Orit; Dvir-Szternfeld, Raz; Ulland, Tyler K.; David, Eyal; Baruch, Kuti; Lara-Astaiso, David; Toth, Beata; Itzkovitz, Shalev; Colonna, Marco; Schwartz, Michal; Amit, Ido
(2017) Cell, volume 169, issue 7, pp. 1276 - 1290.e17
(Article)
Abstract
Alzheimer's disease (AD) is a detrimental neurodegenerative disease with no effective treatments. Due to cellular heterogeneity, defining the roles of immune cell subsets in AD onset and progression has been challenging. Using transcriptional single-cell sorting, we comprehensively map all immune populations in wild-type and AD-transgenic (Tg-AD) mouse brains. We describe ... read more
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Keywords: Alzheimer Disease, Animals, Humans, Mice, Mice, Transgenic, Microglia, Neurodegenerative Diseases, Phagocytes, Receptors, Immunologic, Sequence Analysis, RNA, Single-Cell Analysis, Journal Article, General Biochemistry,Genetics and Molecular Biology, Journal Article
DOI: https://doi.org/10.1016/j.cell.2017.05.018
ISSN: 0092-8674
Publisher: Cell Press
Note: Funding Information: We thank Genia Brodsky for help with the artwork. We thank M. Esiri and A. Troen for their help in obtaining human brain sections. This work was funded by NIH grants RF1AG05148501 (M.C.) and 5T32CA009547-30 (T.K.U.). M.S. is supported by the Advanced European Research Council (232835), by the EU Seventh Framework Program HEALTH-2011 (279017), Israel Science Foundation (ISF)-Legacy-Bio-Med program (1354/15), the Minerva Foundation, and ISF-Neurology (991/16). M.S. holds the Maurice and Ilse Katz Professorial Chair in Neuroimmunology. I.A. is supported by the HHMI International Scholar award, the European Research Council Consolidator Grant (ERC-COG) 724471-HemTree2.0, the Israel Science Foundation (703/15), the Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine, the Helen and Martin Kimmel award for innovative investigation, a Minerva Stiftung research grant, the Israeli Ministry of Science, Technology, and Space, the David and Fela Shapell Family Foundation, the NeuroMac DFG/Transregional Collaborative Research Center Grant, and the Abramson Family Center for Young Scientists. I.A. is the incumbent of the Alan and Laraine Fischer Career Development Chair. A patent application has been filed related to this work. Funding Information: We thank Genia Brodsky for help with the artwork. We thank M. Esiri and A.?Troen for their help in obtaining human brain sections. This work was funded by NIH grants RF1AG05148501 (M.C.) and 5T32CA009547-30 (T.K.U.). M.S. is supported by the Advanced European Research Council (232835), by the EU?Seventh Framework Program HEALTH-2011 (279017), Israel Science Foundation (ISF)-Legacy-Bio-Med program (1354/15), the Minerva Foundation, and ISF-Neurology (991/16). M.S. holds the Maurice and Ilse Katz Professorial Chair in Neuroimmunology. I.A. is supported by the HHMI International Scholar award, the European Research Council Consolidator Grant (ERC-COG) 724471-HemTree2.0, the Israel Science Foundation (703/15), the Ernest and Bonnie Beutler Research Program of Excellence in Genomic Medicine, the Helen and Martin Kimmel award for innovative investigation, a Minerva Stiftung research grant, the Israeli Ministry of Science, Technology, and Space, the David and Fela Shapell Family Foundation, the NeuroMac DFG/Transregional Collaborative Research Center Grant, and the Abramson Family Center for Young Scientists. I.A. is the incumbent of the Alan and Laraine Fischer Career Development Chair. A patent application has been filed related to this work. Publisher Copyright: © 2017 Elsevier Inc.
(Peer reviewed)