Similar pro-NT and pro-RLX2 levels after preeclampsia and after uncomplicated pregnancy
Zoet, G. A.(Gerbrand); van Rijn, B. B.(Bas); Rehfeldt, M. (Miriam); Franx, A. (Arie); Maas, Angela H E M
(2017) Maturitas, volume 106, pp. 87 - 91
(Article)
Abstract
OBJECTIVE: Women are at increased risk of developing cardiovascular disease (CVD) after preeclampsia. Proneurotensin 1-117 (pro-NT) and prorelaxin 2 connecting peptide (pro-RLX2) have recently emerged as potential biomarkers for CVD risk in women. We assessed pro-NT and pro-RLX2 levels in women with and without a history of preeclampsia. STUDY DESIGN:
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339 women with a history of early-onset preeclampsia and 327 women with an uncomplicated pregnancy underwent cardiovascular screening 10 years after delivery (the Preeclampsia Risk EValuation in FEMales (PREVFEM) cohort). MAIN OUTCOME MEASURES: Pro-NT, a stable fragment of the neurotensin precursor, was assessed in the whole cohort. Pro-RLX2, the stable connecting peptide of the relaxin 2 prohormone, was assessed in a subset of this cohort, consisting of 27 women with a history of preeclampsia and 23 healthy controls. Associations between biomarker levels and traditional CVD risk factors in the preeclampsia and control group were assessed by Pearson's correlation coefficient. RESULTS: We found no differences in pro-NT and pro-RLX2 levels between the preeclampsia and control group. Pro-NT levels were associated with higher HbA1c levels (r=0.113, p-value 0.045) and with BMI (r=0.124, p-value 0.027), but only in the control group. Pro-RLX2 was related to current smoking and triglyceride levels in women with a history of preeclampsia and related to LDL-cholesterol in women with an uncomplicated pregnancy. CONCLUSIONS: Pro-NT and pro-RLX2 levels were comparable in women 10 years after preeclampsia and women with an uncomplicated pregnancy. The role of pro-NT and pro-RLX2 in CVD development after preeclampsia should be further investigated.
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Keywords: Adult, Biomarkers, Cardiovascular Diseases, Cohort Studies, Female, Humans, Middle Aged, Neurotensin, Pre-Eclampsia, Pregnancy, Protein Precursors, Relaxin, Risk Factors, Young Adult, Journal Article, General Biochemistry,Genetics and Molecular Biology, Obstetrics and Gynaecology
ISSN: 0378-5122
Publisher: Elsevier Ireland Ltd
Note: Funding Information: GAZ is supported by the Dutch Heart Foundation (grant number 2013T083 ). The Foundation was not involved in the study design, data collection, analyses, writing of the report or in the decision to submit the article for publication. Publisher Copyright: © 2017 Elsevier B.V.
(Peer reviewed)