The El Escorial criteria: Strengths and weaknesses
Agosta, F.; Al-Chalabi, A.; Filippi, Massimo; Hardiman, O.; Kaji, R.; Meininger, V.; Nakano, I.; Shaw, P.; Shefner, J.M.; Van Den Berg, L.H.; Ludolph, A.
(2015) Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration, volume 16, issue 1-2, pp. 1 - 7
(Article)
Abstract
The El Escorial criteria for the diagnosis of amyotrophic lateral sclerosis (ALS) were established 20 years ago and have been used as inclusion criteria for clinical trials. However, concerns have been raised concerning their use as diagnostic criteria in clinical practice. Moreover, as modern genetics have shed new light on
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the heterogeneity of ALS and the close relationship between ALS and frontotemporal dementia (FTD) recognized, the World Federation of Neurology Research Group on ALS/MND has initiated discussions to amend and update the criteria, while preserving the essential components for clinical trial enrolment purposes. © 2014 Informa Healthcare.
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Keywords: amyotrophic lateral sclerosis, Article, clinical practice, clinical trial (topic), diffusion tensor imaging, disease association, disease classification, early diagnosis, El Escorial criteria, electrophysiology, familial disease, frontotemporal dementia, human, nuclear magnetic resonance imaging, priority journal, neuroimaging, neurologic examination, pathophysiology, procedures, severity of illness index, standards, Amyotrophic Lateral Sclerosis, Clinical Trials as Topic, Frontotemporal Dementia, Humans, Neuroimaging, Neurologic Examination, Severity of Illness Index
ISSN: 2167-8421
Publisher: Informa Healthcare
Note: cited By 8
(Peer reviewed)