Carbapenemase-producerende enterobacteriën in Nederland: Onopgemerkte verspreiding naar verschillende regio's

Abstract

Carbapenemase producing Enterobacteriaceae (CPE), including Klebsiella pneumoniae and Escherichia coli, are only sporadically seen in the Netherlands and then mainly in patients who have been transferred from foreign hospitals.. CPE are resistant to virtually all beta-lactam antibiotics, including carbapenems, e.g., meropenem and imipenem. Several genes, e.g., OXA-48, KPC and NDM-1, code for carbapenemase enzymes that deactivate carbapenems.. Control of CPE focuses on timely identification of patients who are infected or are carriers and the application of preventive measures to prevent spread.. Genotypic analysis of CPE isolates submitted to the national CPE surveillance revealed close relationships between 8 NDM-1 positive K. pneumoniae isolates of patients from different parts of the Netherlands and isolates obtained through contact tracing during a known hospital outbreak. - Based on retrospective epidemiological investigation, no shared exposure could be found. - These findings indicate unnoticed spread of CPE in the Netherlands.