Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles

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Concise review: Developing best-practice models for the therapeutic use of extracellular vesicles
 
Reiner, Agnes T.; Witwer, Kenneth W.; Van Balkom, Bas W.M.; De Beer, Joel; Brodie, Chaya; Corteling, Randolph L.; Gabrielsson, Susanne; Gimona, Mario; Ibrahim, Ahmed G.; De Kleijn, Dominique; Lai, Charles P.; Tvall, Jan Lo; Del Portillo, Hernando A; Reischl, Ilona G; Riazifar, Milad; Salomon, Carlos; Tahara, Hidetoshi; Toh, Wei Seong; Wauben, Marca H M; Yang, Vicky K.; Yang, Yijun; Yeo, Ronne Wee Yeh; Yin, Hang; Giebel, Bernd; Rohde, Eva; Lim, Sai Kiang
(2017) Stem Cells Translational Medicine, volume 6, issue 8, pp. 1730 - 1739
(Article)
Abstract
Growing interest in extracellular vesicles (EVs, including exosomes and microvesicles) as therapeutic entities, particularly in stem cell-related approaches, has underlined the need for standardization and coordination of development efforts. Members of the International Society for Extracellular Vesicles and the Society for Clinical Research and Translation of Extracellular Vesicles Singapore convened ... read more
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Keywords: Cellular therapy, Clinical translation, Clinical trials, Exosomes, Extracellular vesicles, Microvesicles, Stem cells, Therapeutics, Developmental Biology, Cell Biology, Journal Article, Review
DOI: https://doi.org/10.1002/sctm.17-0055
ISSN: 2157-6564
Publisher: AlphaMed Press
Note: Funding Information: aBioSensor Technologies, AIT Austrian Institute of Technology, Vienna, Austria; Departments of bMolecular and Comparative Pathobiology and cNeurology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA; dDepartment of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands; eAnjarium Biosciences AG, Zollikon, Switzerland; fDepartment of Neurosurgery, Henry Ford Hospital, Detroit, Michigan, USA; gFaculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel; hReNeuron Group, Pencoed, United Kingdom; iDepartment of Medicine, Unit for Immunology and Allergy, Karolinska Institute, Stockholm, Sweden; jSpinal Cord Injury & Tissue Regeneration Center Salzburg (SCI-TReCS), Paracelsus Medical University (PMU), Salzburg, Austria; kDepartment of Blood Group Serology and Transfusion Medicine, University Hospital, Salzburger Landeskliniken GesmbH (SALK), Salzburg, Austria; lCapricor Therapeutics, Los Angeles, California, USA; mDept. of Vascular Surgery & Cardiology, Utrecht University, Utrecht, The Netherlands; nNUS Surgery & A-STAR, Singapore; oInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu, Taiwan, Republic of China; pKrefting Research Centre, Institute of Medicine, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden; qCodiak BioSciences, Woburn, Massachusetts, USA; rICREA at ISGlobal Barcelona Institute for Global Health, Ctr. Int. Health Res. (CRESIB), Hospital Clínic, University of Barcelona, Barcelona, Spain; sInstitut d’Investigació Germans Trias i Pujol (IGTP), Badalona, Spain; tFederal Office for Safety in Health Care; uAustrian Agency for Health and Food Safety, Institute Surveillance, Vienna, Austria; vDepartment of Pharmaceutical Sciences; wSue and Bill Gross Stem Cell Research Center, University of California, Irvine, California, USA; xCentre for Clinical Research, Royal Brisbane and Women’s Hospital, The University of Queensland, Brisbane, Australia; yDepartment of Obstetrics and Gynecology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA; zDepartment of Cellular and Molecular Biology, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan; aaFaculty of Dentistry, National University of Singapore, Singapore; bbDepartment of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands; ccDepartment of Clinical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts, USA; ddState Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; eeInstitute of Medical Biology, A*STAR, Singapore; ffDepartment of Chemistry and Funding Information: We acknowledge the contributions of all participants of the ISEV-SOCRATES Therapeutics Workshop.We also thank Amanda Steele for assistance with manuscript preparation and editing. Publisher Copyright: © 2017 The Authors.
(Peer reviewed)