Pharmacogenetics of coumarin anticoagulant therapy

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Pharmacogenetics of coumarin anticoagulant therapy
 
van Schie, Rianne M. F.; Verhoef, Talitha I.; de Boer, Anthonius; van der Meer, Felix J. M.; Redekop, William K.; Schalekamp, Tom; Maitland-Van der Zee, Anke-Hilse
(2015) Grech, Godfrey (ed.), Preventive and Predictive Genetics, pp. 307 - 328
Advances in Predictive, Preventive and Personalised Medicine, pp. 307 - 328
(Part of book)
Abstract
Coumarins are effective drugs for treatment and prevention of thromboembolic events. However, their use requires a balancing act between the chance of underdosing which increases the risk of thromboembolic events and the chance of overdosing which increases the risk of haemorrhages. It has been shown that polymorphisms in VKORC1 and ... read more
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Keywords: Adverse drug reaction, Pharmacogenetics, Predictive genotyping, Translation, abacavir, coumarin, phenprocoumon, warfarin, anticoagulant therapy, bleeding, clinical practice, clinical trial (topic), cost effectiveness analysis, drug stability, environmental factor, genetic polymorphism, genetic variability, genotype, human, pharmacogenetics, predictive value, quality adjusted life year, thrombocytopenia, venous thromboembolism, Taverne
DOI: https://doi.org/10.1007/978-3-319-15344-5_11
ISSN: 2211-3495
ISBN: 978-3-319-15343-8
978-3-319-15344-5
Publisher: Kluwer Academic Publishers, UK
(Peer reviewed)
 
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