Alzheimer's biomarkers in daily practice (ABIDE) project: Rationale and design
de Wilde, Arno; van Maurik, Ingrid S.; Kunneman, Marleen; Bouwman, Femke; Zwan, Marissa; Willemse, Eline A J; Biessels, Geert Jan; Minkman, Mirella; Pel, Ruth; Schoonenboom, Niki S M; Smets, Ellen M A; Wattjes, Mike P.; Barkhof, Frederik; Stephens, Andrew; van Lier, Erik J.; Batrla-Utermann, Richard; Scheltens, Philip; Teunissen, Charlotte E.; van Berckel, Bart N M; van der Flier, Wiesje M.
(2017) Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, volume 6, pp. 143 - 151
(Article)
Abstract
INTRODUCTION: The Alzheimer's biomarkers in daily practice (ABIDE) project is designed to translate knowledge on diagnostic tests (magnetic resonance imaging [MRI], cerebrospinal fluid [CSF], and amyloid positron emission tomography [PET]) to daily clinical practice with a focus on mild cognitive impairment (MCI). METHODS: ABIDE is a 3-year project with a
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multifaceted design and is structured into interconnected substudies using both quantitative and qualitative research methods. RESULTS: Based on retrospective data, we develop personalized risk estimates for MCI patients. Prospectively, we collect MRI and CSF data from 200 patients from local memory clinics and amyloid PET from 500 patients in a tertiary setting, to optimize application of these tests in daily practice. Furthermore, ABIDE will develop strategies for optimal patient-clinician conversations. DISCUSSION: Ultimately, this will result in a set of practical tools for clinicians to support the choice of diagnostic tests and facilitate the interpretation and communication of their results.
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Keywords: Alzheimer's disease, Biomarkers, Clinical practice, Dementia, Mild cognitive impairment, Clinical Neurology, Psychiatry and Mental health, Journal Article
Publisher: John Wiley & Sons Inc.
Note: Publisher Copyright: © 2017 The Authors Copyright: Copyright 2018 Elsevier B.V., All rights reserved.
(Peer reviewed)
