Biomarkers of folate and vitamin B12 and breast cancer risk: Report from the EPIC cohort
Matejcic, M.; de Batlle, J.; Ricci, C.; Biessy, C.; Perrier, F.; Huybrechts, I.; Weiderpass, E.; Boutron-Ruault, M. C.; Cadeau, C.; His, M.; Cox, D. G.; Boeing, H.; Fortner, R. T.; Kaaks, R.; Lagiou, P.; Trichopoulou, A.; Benetou, V.; Tumino, R.; Panico, S.; Sieri, S.; Palli, D.; Ricceri, F.; Bueno-de-Mesquita, H. Bas; Skeie, G.; Amiano, P.; Sánchez, M. J.; Chirlaque, M. D.; Barricarte, A.; Quirós, J. R.; Buckland, G.; van Gils, C. H.; Peeters, P. H.; Key, T. J.; Riboli, E.; Gylling, B.; Zeleniuch-Jacquotte, A.; Gunter, M. J.; Romieu, I.; Chajès, V.
(2017) International Journal of Cancer, volume 140, issue 6, pp. 1246 - 1259
(Article)
Abstract
Epidemiological studies have reported inconsistent findings for the association between B vitamins and breast cancer (BC) risk. We investigated the relationship between biomarkers of folate and vitamin B12 and the risk of BC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Plasma concentrations of folate and vitamin
... read more
B12 were determined in 2,491 BC cases individually matched to 2,521 controls among women who provided baseline blood samples. Multivariable logistic regression models were used to estimate odds ratios by quartiles of either plasma B vitamin. Subgroup analyses by menopausal status, hormone receptor status of breast tumors (estrogen receptor [ER], progesterone receptor [PR] and human epidermal growth factor receptor 2 [HER2]), alcohol intake and MTHFR polymorphisms (677C > T and 1298A > C) were also performed. Plasma levels of folate and vitamin B12 were not significantly associated with the overall risk of BC or by hormone receptor status. A marginally positive association was found between vitamin B12 status and BC risk in women consuming above the median level of alcohol (OR Q4-Q1 = 1.26; 95% CI 1.00–1.58; P trend = 0.05). Vitamin B12 status was also positively associated with BC risk in women with plasma folate levels below the median value (OR Q4-Q1 = 1.29; 95% CI 1.02–1.62; P trend = 0.03). Overall, folate and vitamin B12 status was not clearly associated with BC risk in this prospective cohort study. However, potential interactions between vitamin B12 and alcohol or folate on the risk of BC deserve further investigation.
show less
Download/Full Text
The full text of this publication is not available.
Keywords: alcohol, breast cancer, folate, hormone receptor status, MTHFR polymorphism, plasma biomarkers, vitamin B12, General Medicine, Oncology, Cancer Research, Journal Article, Multicenter Study
ISSN: 0020-7136
Publisher: Wiley-Liss Inc.
Note: Publisher Copyright: © 2016 UICC
(Peer reviewed)