Embryo-maternal communication during the first 4 weeks of equine pregnancy

Abstract

The first month of equine pregnancy covers a period of rapid growth and development, during which the single-cell zygote metamorphoses into an embryo with a functional circulation and precursors of many important organs, enclosed within extraembryonic membranes responsible for nutrient uptake and gaseous exchange. After exiting the oviduct, the conceptus must influence uterine physiology to ensure adequate nutrition and preparation for implantation, while continued development results in the chorioallantois superseding the yolk sac as the primary interface for maternal interaction and exchange. Throughout the first month, pregnancy maintenance depends absolutely on progesterone secreted by the primary corpus luteum. However, although extension of luteal life span via maternal recognition of pregnancy is clearly essential, it is still not known how the horse conceptus signals its presence. On the other hand, our understanding of how luteolytic prostaglandin F2α release from the endometrium is averted has improved, and we are increasingly aware of the biological and practical significance of various events characteristic of early horse pregnancy, such as selective oviductal transport, the formation and dissolution of the blastocyst capsule, and prolonged intrauterine conceptus migration. It is also increasingly clear that embryo-maternal dialog during the first month is essential not only to conceptus survival but also has more profound and long-lasting implications. In this latter respect, it is now accepted that the maternal environment (e.g., metabolic or health status) may epigenetically alter gene expression capacity of the developing embryo and thereby permanently influence the health of the resulting foal right through adulthood.