Reproducibility and variability of quantitative magnetic resonance imaging markers in cerebral small vessel disease
De Guio, François; Jouvent, Eric; Biessels, Geert Jan; Black, Sandra E.; Brayne, Carol; Chen, Christopher; Cordonnier, Charlotte; De Leeuw, Frank Eric; Dichgans, Martin; Doubal, Fergus; Duering, Marco; Dufouil, Carole; Duzel, Emrah; Fazekas, Franz; Hachinski, Vladimir; Ikram, M. Arfan; Linn, Jennifer; Matthews, Paul M.; Mazoyer, Bernard; Mok, Vincent; Norrving, Bo; O'Brien, John T.; Pantoni, Leonardo; Ropele, Stefan; Sachdev, Perminder; Schmidt, Reinhold; Seshadri, Sudha; Smith, Eric E.; Sposato, Luciano A.; Stephan, Blossom; Swartz, Richard H.; Tzourio, Christophe; Van Buchem, Mark; Van Der Lugt, Aad; Van Oostenbrugge, Robert; Vernooij, Meike W.; Viswanathan, Anand; Werring, David; Wollenweber, Frank; Wardlaw, Joanna M.; Chabriat, Hugues
(2016) Journal of Cerebral Blood Flow and Metabolism, volume 36, issue 8, pp. 1319 - 1337
(Article)
Abstract
Brain imaging is essential for the diagnosis and characterization of cerebral small vessel disease. Several magnetic resonance imaging markers have therefore emerged, providing new information on the diagnosis, progression, and mechanisms of small vessel disease. Yet, the reproducibility of these small vessel disease markers has received little attention despite being
... read more
widely used in cross-sectional and longitudinal studies. This review focuses on the main small vessel disease-related markers on magnetic resonance imaging including: white matter hyperintensities, lacunes, dilated perivascular spaces, microbleeds, and brain volume. The aim is to summarize, for each marker, what is currently known about: (1) its reproducibility in studies with a scan-rescan procedure either in single or multicenter settings; (2) the acquisition-related sources of variability; and, (3) the techniques used to minimize this variability. Based on the results, we discuss technical and other challenges that need to be overcome in order for these markers to be reliably used as outcome measures in future clinical trials. We also highlight the key points that need to be considered when designing multicenter magnetic resonance imaging studies of small vessel disease.
show less
Download/Full Text
The full text of this publication is not available.
Keywords: atrophy, brain volume, cerebral small vessel disease, lacunes, Magnetic resonance imaging, marker, microbleeds, perivascular spaces, repeatability, reproducibility, variability, white matter hyperintensities, Neurology, Clinical Neurology, Cardiology and Cardiovascular Medicine, Journal Article, Review
ISSN: 0271-678X
Publisher: Nature Publishing Group
(Peer reviewed)