PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery

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PEG stabilized DNA-poly(ferrocenylsilane) polyplexes for gene delivery
 
Zoetebier, B.; Sohrabi, A.; Lou, B.; Hempenius, M. A.; Hennink, W. E.; Vancso, G. J.
(2016) Chemical Communications, volume 52, issue 49, pp. 7707 - 7710
(Article)
Abstract
Polycationic poly(ferrocenylsilane)s (PFS) with tunable amounts of PEG side chains were used for the condensation of DNA into polyplexes of 110 nm in 5.0 mM HEPES. The PFS-PEG/DNA polyplexes showed negligible aggregation, a strongly reduced protein adsorption, transfection activities comparable with linear polyethyleneimine and an excellent cytocompatibility.
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Keywords: Taverne, General Chemistry, Catalysis, Ceramics and Composites, Electronic, Optical and Magnetic Materials, Surfaces, Coatings and Films, Materials Chemistry, Metals and Alloys
DOI: https://doi.org/10.1039/c6cc02733d
ISSN: 1359-7345
Publisher: Royal Society of Chemistry
(Peer reviewed)
 
 
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