An international Ki67 reproducibility study in adrenal cortical Carcinoma
Papathomas, Thomas G.; Pucci, Eugenio; Giordano, Thomas J.; Lu, Hao; Duregon, Eleonora; Volante, Marco; Papotti, Mauro; Lloyd, Ricardo V.; Tischler, Arthur S.; Van Nederveen, Francien H.; Nose, Vania; Erickson, Lori; Mete, Ozgur; Asa, Sylvia L.; Turchini, John; Gill, Anthony J.; Matias-Guiu, Xavier; Skordilis, Kassiani; Stephenson, Timothy J.; Tissier, Frederique; Feelders, Richard A.; Smid, Marcel; Nigg, Alex; Korpershoek, Esther; Van Der Spek, Peter J.; Dinjens, Winand N M; Stubbs, Andrew P.; De Krijger, Ronald R.
(2016) American Journal of Surgical Pathology, volume 40, issue 4, pp. 569 - 576
(Article)
Abstract
Despite the established role of Ki67 labeling index in prognostic stratification of adrenocortical carcinomas and its recent integration into treatment flow charts, the reproducibility of the assessment method has not been determined. The aim of this study was to investigate interobserver variability among endocrine pathologists using a web-based virtual microscopy
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approach. Ki67-stained slides of 76 adrenocortical carcinomas were analyzed independently by 14 observers, each according to their method of preference including eyeballing, formal manual counting, and digital image analysis. The interobserver variation was statistically significant (P
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Keywords: Adrenal cortical carcinoma, Digital pathology, Interobserver variation, Ki67 labeling index, Proliferation, Anatomy, Surgery, Pathology and Forensic Medicine, Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't
ISSN: 0147-5185
Publisher: Lippincott Williams and Wilkins
(Peer reviewed)