Population differences and the effect of vaginal progesterone on preterm birth in women with threatened preterm labor*
Hermans, Frederik Jan Robin; Karolinski, Ariel; Othenin-Girard, Véronique; Bertolino, María Victoria; Schuit, Ewoud; Salgado, Pablo; Hösli, Irene; Irion, Olivier; Laterra, Cristina; Mol, Ben Willem J; Martinez de Tejada, Begoña
(2016) Journal of Maternal-fetal & Neonatal Medicine, volume 29, issue 19, pp. 3223 - 3228
(Article)
Abstract
Objective: Threatened preterm labor (tPTL) is a complication of pregnancy. Identification of women and clinical definition differs between countries. This study investigated differences in tPTL and effectiveness of vaginal progesterone to prevent preterm birth (PTB) between two countries. Methods: Secondary analysis of a randomized controlled trial (RCT) from Argentina and
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Switzerland comparing vaginal progesterone to placebo in women with tPTL (n = 379). Cox proportional hazards analysis was performed to compare placebo groups of both countries and to compare progesterone to placebo within each country. We adjusted for baseline differences. Iatrogenic onset of labor or pregnancy beyond gestational age of interest was censored. Results: Swiss and Argentinian women were different on baseline. Risks for delivery
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Keywords: Harm, population differences, preterm birth, randomized controlled trial, secondary analysis, selection criteria, threatened preterm labor, treatment effect, treatment interaction, vaginal progesterone, Pediatrics, Perinatology, and Child Health, Obstetrics and Gynaecology, Journal Article, Comparative Study, Randomized Controlled Trial
ISSN: 1476-7058
Publisher: Informa Healthcare
(Peer reviewed)