Molecular epidemiology of MRSA in 13 ICUs from eight European countries
Hetem, D. J.; Derde, L. P G; Empel, J.; Mroczkowska, A.; Orczykowska-Kotyna, M.; Kozińska, A.; Hryniewicz, W.; Goossens, H.; Bonten, M. J M; Cooper, B.; Malhotra-Kumar, S.; Willems, R.; Gniadkowski, M.; Dautzenberg, M.; Annane, D.; Aragão, I.; Chalfine, A.; Dumpis, U.; Esteves, F.; Giamarellou, H.; Muzlovic, I.; Nardi, G.; Petrikkos, G.; Tomic, V.; Torres Martí, A.; Stammet, P.; Brun-Buisson, C.; Aires, E.; Antoniadou, A.; Armaganidis, A.; Blairon, F.; Carneiro, J.; Chaskou, D.; Coppadoro, P.; Dias, A. P.; Drinovec, I.; Elia, M.; Exarchou, V.; Flet, A.; Fournier, J.; Gillet, N.; Jaklič, A.; Jereb, M.; Kane, A.; Karkali, E.; Kieffer, J.; Kirpach, P.; Landelle, C.; Landercy, F.; Lawrence, C.; Legrand, P.; Lopes, V.; Magira, E.; Marco, F.; Martínez, J. A.; Melbarde-Kelmere, A.; Misset, B.; Monte, R.; Moreno, E.; Nguyen, J. C.; Novak, M.; Orazi, D.; Papadomichelakis, E.; Papaparaskevas, J.; Paris, M.; Pavleas, J.; Pimenta, F.; Piñer, R.; Radouan, A.; Ramunno, M. G.; Reis, M.; Rinaldi, I.; Ronco, E.; San Jose, A.; Seme, K.; Skiada, A.; Trapassi, S.; Tronci, M.; Verachten, M.; Vila, J.; Vrankar, K.; Winkler, M.; Zagavierou, S.; Hopman, M.; Leus, F.; Schotsman, J.; Zwerver, J.
(2016) Journal of Antimicrobial Chemotherapy, volume 71, issue 1, pp. 45 - 52
(Article)
Abstract
Objectives: The European epidemiology of MRSA is changing with the emergence of community-associated MRSA (CA-MRSA) and livestock-associated MRSA (LA-MRSA). In this study,we investigated the molecular epidemiology of MRSA during 2 years in 13 ICUs in France, Greece, Italy, Latvia, Luxemburg, Portugal, Slovenia and Spain. Methods: Surveillance cultures for MRSA from
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nose and wounds were obtained on admission and twice weekly from all patients admitted to an ICU for ≥3 days. The first MRSA isolate per patient was genotyped in a central laboratory by MLST, spa typing, agr typing and SCCmec (sub)typing. Risk factors for patients with an unknown history of MRSA colonization were identified. Results: Overall, 14390 ICU patients were screened, of whom 8519 stayed in an ICU for ≥3 days. Overall MRSA admission prevalence was 3.9% and ranged from 1.0% to 7.0% for individual ICUs. Overall MRSA acquisition rate was 2.5/1000 patient days at risk and ranged from 0.2 to 8/1000 patient days at risk per ICU. In total, 557 putative MRSA isolates were submitted to the central laboratory for typing, of which 511 (92%) were confirmed as MRSA. Each country had a distinct epidemiology, with ST8-IVc (UK-EMRSA-2/-6, USA500) being most prevalent, especially in France and Spain, and detected in ICUs in five of eight countries. Seventeen (3%) and three (70 years and hospitalization within 1 year prior to ICU admission. Conclusions: The molecular epidemiology of MRSA in 13 European ICUs in eight countries was homogeneous within, but heterogeneous between, countries. CA-MRSA and LA-MRSA genotypes and Panton-Valentine leucocidin-producing isolates were detected sporadically.
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Keywords: General Medicine, Pharmacology, Infectious Diseases, Pharmacology (medical), Journal Article
ISSN: 0305-7453
Publisher: Oxford University Press
(Peer reviewed)