No association between transient hypothyroxinemia of prematurity and neurodevelopmental outcome in young adulthood
Hollanders, Jonneke J.; Israëls, Joël; Van Der Pal, Sylvia M.; Verkerk, Paul H.; Rotteveel, Joost; Finken, Martijn J J; Hille, E. T M; De Groot, C. H.; Kloosterboer-Boerrigter, H.; Den Ouden, A. L.; Rijpstra, A.; Verloove-Vanhorick, S. P.; Vogelaar, J. A.; Kok, J. H.; Ilsen, A.; Van Der Lans, M.; Boelen-Van Der Loo, W. J C; Lundqvist, T.; Heymans, H. S A; Duiverman, E. J.; Geven, W. B.; Duiverman, M. L.; Geven, L. I.; Vrijlandt, E. J L E; Mulder, A. L M; Gerver, A.; Kollée, L. A A; Reijmers, L.; Sonnemans, R.; Wit, J. M.; Dekker, F. W.; Finken, M. J J; Weisglas-Kuperus, N.; Keijzer-Veen, M. G.; Van Der Heijden, A. J.; Van Goudoever, J. B.; Van Weissenbruch, M. M.; Cranendonk, A.; Delemarre-Van De Waal, H. A.; De Groot, L.; Samsom, J. F.; De Vries, L. S.; Rademaker, K. J.; Moerman, E.; Voogsgeerd, M.; De Kleine, M. J K; Andriessen, P.; Dielissen-Van Helvoirt, C. C M; Mohamed, I.; Van Straaten, H. L M; Baerts, W.; Veneklaas Slots-Kloosterboer, G. W.; Tuller-Pikkemaat, E. M J; Ens-Dokkum, M. H.; Van Steenbrugge, G. J.
(2015) Journal of Clinical Endocrinology and Metabolism, volume 100, issue 12, pp. 4648 - 4653
(Article)
Abstract
Context: Transient hypothyroxinemia of prematurity (THoP) has been associated with neurodevelopmental impairment in infancy and childhood. It is not known whether these relations persist into adulthood. Objective: The objective was to examine whether there is an effect of THoP on intelligence quotient (IQ) score and motor functioning at a young
... read more
adult age. Design: This study was part of the 19-year follow-up of the Project On Preterm and Small-forgestational-age birth (POPS) cohort, which included infants born very preterm (ie,32 wk) and/or with a very low birth weight (ie, 1500 g). Setting: This was a multicenter study. Patients: There were 398 19-year-old participants of the POPS cohort, of whom 120 had THoP. Exposure: T4 concentrations were obtained through the national neonatal screening program for congenital hypothyroidism.THoP was defined as a total T4 concentration< -3 SD of the daily mean (approximately 60 nmol/L). Main Outcome Measures: Main outcome measures were IQ and motor functioning, measured with the digital Multicultural Capacities Test-Intermediate Level and a revised version of Touwen’s examination of minor neurological dysfunction, respectively. Results: THoP was not associated with IQ score (mean difference, 0 [95% confidence interval,3.8 to 3.8] points) or motor function (mean difference, 0.6 [95% confidence interval, 1.3 to 2.5] points) after adjustment for demographic and perinatal characteristics. Conclusions: No associations between THoP and neurodevelopmental outcome at age 19 years were found.
show less
Download/Full Text
The full text of this publication is not available.
Keywords: Endocrinology, Diabetes and Metabolism, Biochemistry, Endocrinology, Clinical Biochemistry, Biochemistry, medical, Journal Article, Research Support, Non-U.S. Gov't
ISSN: 0021-972X
Publisher: The Endocrine Society
(Peer reviewed)