Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy

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Site-specific conjugation of single domain antibodies to liposomes enhances photosensitizer uptake and photodynamic therapy efficacy
 
Broekgaarden, M.; Van Vught, R.; Oliveira, Sabrina; Roovers, R. C.; Van Bergen En Henegouwen, P. M P; Pieters, R. J.; Van Gulik, T. M.; Breukink, E.; Heger, M.
(2016) Nanoscale, volume 8, issue 12, pp. 6490 - 6494
(Article)
Abstract
Photodynamic therapy for therapy-resistant cancers will greatly benefit from targeted delivery of tumor photosensitizing agents. In this study, a strategy for the site-specific conjugation of single domain antibodies onto liposomes containing the photosensitizer zinc phthalocyanine was developed and tested.
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Open Access version via Utrecht University Repository Publisher version
 
Keywords: Taverne, General Materials Science
DOI: https://doi.org/10.1039/c6nr00014b
ISSN: 2040-3364
Publisher: Royal Society of Chemistry
(Peer reviewed)
 
 
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