Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Tunjungputri, Rahajeng N.; De Jonge, Marien I.; De Greeff, Astrid; Van Selm, Saskia; Buys, Herma; Harders-Westerveen, Jose F.; Stockhofe-Zurwieden, Norbert; Urbanus, Rolf T.; de Groot, Phillip G.; Smith, Hilde E.; Van Der Ven, Andre J.; De Mast, Quirijn

doi:https://doi.org/10.1016/j.thromres.2016.06.016

Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

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Invasive pneumococcal disease leads to activation and hyperreactivity of platelets

Tunjungputri, Rahajeng N.; De Jonge, Marien I.; De Greeff, Astrid; Van Selm, Saskia; Buys, Herma; Harders-Westerveen, Jose F.; Stockhofe-Zurwieden, Norbert; Urbanus, Rolf T.; de Groot, Phillip G.; Smith, Hilde E.; Van Der Ven, Andre J.; De Mast, Quirijn

(2016) Thrombosis Research, volume 144, pp. 123 - 126

(Letter)

Abstract

Using a novel porcine model of intravenous Streptococcus pneumoniae infection, we showed that invasive pneumococcal infections induce marked platelet activation and hyperreactivity. This may contribute to the vascular complications seen in pneumococcal infection.

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Keywords: Infection, Myocardial infarction, Platelet activation, Platelets, Pneumonia, Streptococcus pneumoniae, Hematology, Letter

DOI: https://doi.org/10.1016/j.thromres.2016.06.016

ISSN: 0049-3848

Publisher: Elsevier Limited

(Peer reviewed)