Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study
Ambatipudi, Srikant; Cuenin, Cyrille; Hernandez-Vargas, Hector; Ghantous, Akram; Le Calvez-Kelm, Florence; Kaaks, Rudolf; Barrdahl, Myrto; Boeing, Heiner; Aleksandrova, Krasimira; Trichopoulou, Antonia; Lagiou, Pagona; Naska, Androniki; Palli, Domenico; Krogh, Vittorio; Polidoro, Silvia; Tumino, Rosario; Panico, Salvatore; Bueno-De-Mesquita, Bas; Peeters, Petra HM; Quirós, José Ramón; Navarro, Carmen; Ardanaz, Eva; Dorronsoro, Miren; Key, Tim; Vineis, Paolo; Murphy, Neil; Riboli, Elio; Romieu, Isabelle; Herceg, Zdenko
(2016) Epigenomics, volume 8, issue 5, pp. 599 - 618
(Article)
Abstract
Aim: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure. Materials & methods: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in
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a large multinational cohort. Results: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation. Conclusion: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.
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Keywords: DNA methylome, epigenetic signature, prospective cohort, tobacco smoking, Genetics, Cancer Research, Journal Article
ISSN: 1750-1911
Publisher: Future Medicine Ltd.
(Peer reviewed)