Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease

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Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease
 
Gutierrez-Achury, Javier; Zhernakova, Alexandra; Pulit, Sara L; Trynka, Gosia; Hunt, Karen A; Romanos, Jihane; Raychaudhuri, Soumya; van Heel, David A; Wijmenga, Cisca; de Bakker, Paul I W
(2015) Nature Genetics, volume 47, issue 6, pp. 577 - 8
(Article)
Abstract
Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region. We fine mapped the MHC association signal to identify additional risk factors independent of the HLA-DQA1 and HLA-DQB1 alleles and observed five new associations that account for ... read more
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Keywords: Case-Control Studies, Celiac Disease, Chromosome Mapping, Genetic Association Studies, Genetic Predisposition to Disease, HLA-DQ alpha-Chains, HLA-DQ beta-Chains, Haplotypes, Humans, Risk, Risk Factors
DOI: https://doi.org/10.1038/ng.3268
ISSN: 1061-4036
Publisher: Nature Publishing Group
(Peer reviewed)