Abstract
Background and Purpose Whether NO, carbon monoxide (CO) and hydrogen sulfide (H<inf>2</inf>S) compensate for each other when one or more is depleted is unclear. Inhibiting NOS causes hypertension and kidney injury. Both global depletion of H<inf>2</inf>S by cystathionine γ-lyase (CSE) gene deletion and low levels of exogenous H<inf>2</inf>S cause hypertension.
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