A bioassay using intestinal organoids to measure CFTR modulators in human plasma

Dekkers, R; Vijftigschild, L A W; Vonk, A M; Kruisselbrink, E; de Winter-de Groot, K M; Janssens, H M; van der Ent, C K; Beekman, J M; van der Ent, CK

doi:https://doi.org/10.1016/j.jcf.2014.10.007

A bioassay using intestinal organoids to measure CFTR modulators in human plasma

DSpace/Manakin Repository

A bioassay using intestinal organoids to measure CFTR modulators in human plasma

Dekkers, R; Vijftigschild, L A W; Vonk, A M; Kruisselbrink, E; de Winter-de Groot, K M; Janssens, H M; van der Ent, C K; Beekman, J M; van der Ent, CK

(2015) Journal of Cystic Fibrosis, volume 14, issue 2, pp. 178 - 181

(Article)

Abstract

Treatment efficacies of drugs depend on patient-specific pharmacokinetic and pharmacodynamic properties. Here, we developed an assay to measure functional levels of the CFTR potentiator VX-770 in human plasma and observed that VX-770 in plasma from different donors induced variable CFTR function in intestinal organoids. This assay can help to understand ... read more

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Keywords: Journal Article, Research Support, Non-U.S. Gov't

DOI: https://doi.org/10.1016/j.jcf.2014.10.007

ISSN: 1569-1993

Publisher: Elsevier

(Peer reviewed)