Vitamin e intake, α-tocopherol levels and pulmonary function in children and adolescents with cystic fibrosis
Woestenenk, Janna W.; Broos, Nancy; Stellato, Rebecca; Arets, Hubertus G M; Van Der Ent, Cornelis K.; Houwen, Roderick H J; Arets, HGM
(2015) British Journal of Nutrition, volume 113, issue 7, pp. 1096 - 1101
(Article)
Abstract
Pancreatic insufficiency cystic fibrosis (CF) patients receive vitamin E supplementation according to CF-specific recommendations in order to prevent deficiencies. It has been suggested that higher serum α-tocopherol levels could have protective effects on pulmonary function (PF) in patients with CF. Whether current recommendations are indeed optimal for preventing deficiency and
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whether vitamin E has therapeutic benefits are subjects of debate. Therefore, we studied vitamin E intake as well as the long-term effects of vitamin E intake, the coefficient of fat absorption (CFA) and IgG on α-tocopherol levels. We also examined the long-term effects of serum α-tocopherol and serum IgG on forced expiratory volume in 1 s expressed as percentage of predicted (FEV1% pred.) in paediatric CF patients during a 7-year follow-up period. We found that CF patients failed to meet the CF-specific vitamin E recommendations, but serum α-tocopherol below the 2·5th percentile was found in only twenty-three of the 1022 measurements (2 %). Furthermore, no clear effect of vitamin E intake or the CFA on serum α-tocopherol was found (both P≥ 0·103). FEV1% pred. was longitudinally inversely associated with age (P< 0·001) and serum IgG (P= 0·003), but it was not related to serum α-tocopherol levels. We concluded that in the present large sample of children and adolescents with CF, vitamin E intake was lower than recommended, but serum α-tocopherol deficiency was rare. We found no evidence that higher serum α-tocopherol levels had protective effects on PF. Adjustment of the recommendations to the real-life intake of these patients may be considered.
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Keywords: Adolescent, Adolescent Development, Child, Child Development, Child Nutritional Physiological Phenomena, Child, Preschool, Cohort Studies, Cystic Fibrosis, Diet, Dietary Supplements, Disease Progression, Female, Humans, Infant, Intestinal Absorption, Longitudinal Studies, Male, Netherlands, Patient Compliance, Practice Guidelines as Topic, Respiratory System, Retrospective Studies, Vitamin E, Vitamin E Deficiency, alpha-Tocopherol, Medicine (miscellaneous), Nutrition and Dietetics, General Medicine, Journal Article
ISSN: 0007-1145
Publisher: Cambridge University Press
(Peer reviewed)