Accelerated corpus callosum development in prematurity predicts improved outcome
Thompson, Deanne K.; Lee, Katherine J.; van Bijnen, Loeka; Leemans, Alexander; Pascoe, Leona; Scratch, Shannon E.; Cheong, Jeanie; Egan, Gary F.; Inder, Terrie E.; Doyle, Lex W.; Anderson, Peter J.
(2015) Human Brain Mapping, volume 36, issue 10, pp. 3733 - 3748
(Article)
Abstract
Objectives: To determine: (1) whether corpus callosum (CC) size and microstructure at 7 years of age or their change from infancy to 7 years differed between very preterm (VP) and full-term (FT) children; (2) perinatal predictors of CC size and microstructure at 7 years; and (3) associations between CC measures
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at 7 years or trajectories from infancy to 7 years and neurodevelopmental outcomes. Experimental design: One hundred and thirty-six VP (gestational age [GA] <30 weeks and/or birth weight <1,250 g) and 33 FT children had usable magnetic resonance images at 7 years of age, and of these, 76 VP and 16 FT infants had usable data at term equivalent age. The CC was traced and divided into six sub-regions. Fractional anisotropy, mean, axial, radial diffusivity and volume were measured from tractography. Perinatal data were collected, and neurodevelopmental tests administered at 7 years' corrected age. Principal observations: VP children had smaller posterior CC regions, higher diffusivity and lower fractional anisotropy compared with FT 7-year-olds. Reduction in diffusivity over time occurred faster in VP than FT children (P≤0.002). Perinatal brain abnormality and earlier GA were associated with CC abnormalities. Microstructural abnormalities at 7 years or slower development of the CC were associated with motor dysfunction, poorer mathematics and visual perception. Conclusions: This study is the first to demonstrate an accelerated trajectory of CC white matter diffusion following VP birth, associated with improved neurodevelopmental functioning. Findings suggest there is a window of opportunity for neurorestorative intervention to improve outcomes.
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Keywords: diffusion-weighted imaging, MRI, Neurodevelopment, Preterm, White matter, Clinical Neurology, Anatomy, Neurology, Radiology Nuclear Medicine and imaging, Radiological and Ultrasound Technology, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't
ISSN: 1065-9471
Publisher: Wiley-Liss Inc.
(Peer reviewed)