Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case

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Cell-free fetal DNA in the maternal circulation originates from the cytotrophoblast: proof from an unique case
 
Hochstenbach, Ron; Nikkels, Peter G J; Elferink, Martin G; Oudijk, Martijn A; van Oppen, Carla; van Zon, Patrick; van Harssel, Jeske; Schuring-Blom, Heleen; Page-Christiaens, Godelieve C M L
(2015) Clinical case reports, volume 3, issue 6, pp. 489 - 91
(Article)
Abstract
Noninvasive prenatal testing (NIPT) and direct karyotyping of cytotrophoblast were normal for a male fetus, but cultured chorionic villus mesenchymal cells and umbilical cord fibroblasts showed nonmosaic trisomy 18. This observation provides direct evidence for the cytotrophoblastic origin of cell-free fetal DNA and yields a biological explanation for falsely reassuring ... read more
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Keywords: Journal Article
DOI: https://doi.org/10.1002/ccr3.285
ISSN: 2050-0904
Publisher: John Wiley and Sons Ltd
(Peer reviewed)