The Neonatal Connectome During Preterm Brain Development
van den Heuvel, Martijn P; Kersbergen, Karina J; de Reus, Marcel A; Keunen, Kristin; Kahn, René S; Groenendaal, Floris; de Vries, Linda S; Benders, Manon J N L
(2015) Cerebral Cortex, volume 25, issue 9, pp. 3000 - 3013
(Article)
Abstract
The human connectome is the result of an elaborate developmental trajectory. Acquiring diffusion-weighted imaging and resting-state fMRI, we studied connectome formation during the preterm phase of macroscopic connectome genesis. In total, 27 neonates were scanned at week 30 and/or week 40 gestational age (GA). Examining the architecture of the neonatal
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anatomical brain network revealed a clear presence of a small-world modular organization before term birth. Analysis of neonatal functional connectivity (FC) showed the early formation of resting-state networks, suggesting that functional networks are present in the preterm brain, albeit being in an immature state. Moreover, structural and FC patterns of the neonatal brain network showed strong overlap with connectome architecture of the adult brain (85 and 81%, respectively). Analysis of brain development between week 30 and week 40 GA revealed clear developmental effects in neonatal connectome architecture, including a significant increase in white matter microstructure (P
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Keywords: connectome, development, functional connectivity, neonatal, structural connectivity, RICH-CLUB ORGANIZATION, HUMAN CEREBRAL-CORTEX, RESTING-STATE NETWORKS, INTRINSIC FUNCTIONAL CONNECTIVITY, GRAPH-THEORETICAL ANALYSIS, WHITE-MATTER DEVELOPMENT, DEVELOPING RHESUS-MONKEY, STRUCTURAL CONNECTIVITY, CORTICAL NETWORKS, SMALL-WORLD, Journal Article, Research Support, Non-U.S. Gov't
ISSN: 1047-3211
Publisher: Oxford University Press
Note: © The Author 2014. Published by Oxford University Press.
(Peer reviewed)