Performance analysis of a dedicated breast MR-HIFU system for tumor ablation in breast cancer patients
Deckers, R.; Merckel, L. G.; de Senneville, B. Denis; Schubert, G.; Koehler, M.; Knuttel, F.M.; Mali, W.P.Th.M.; Moonen, C. T. W.; van den Bosch, Maurice; Bartels, L. W.
(2015) Physics in Medicine and Biology, volume 60, issue 14, pp. 5527 - 5542
(Article)
Abstract
MR-guided HIFU ablation is a promising technique for the non-invasive treatment of breast cancer. A phase I study was performed to assess the safety and treatment accuracy and precision of MR-HIFU ablation in breast cancer patients (n = 10) using a newly developed MR-HIFU platform dedicated to applications in the
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breast. In this paper a technical analysis of the performance of the dedicated breast MR-HIFU system during breast tumors ablation is described. The main points of investigation were the spatial targeting accuracy and precision of the system and the performance of real-time respiration-corrected MR thermometry. The mean targeting accuracy was in the range of 2.4-2.6 mm, whereas the mean targeting precision was in the range of 1.5-1.8 mm. To correct for respiration-induced magnetic field fluctuations during MR temperature mapping a look-up-table (LUT)-based correction method was used. An optimized procedural sedation protocol in combination with the LUT-based correction method allowed for precise MR thermometry during the ablation procedure (temperature standard deviation
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Author keywords: high intensity focused ultrasound, thermometry, breast cancer, MRI, FOCUSED ULTRASOUND SURGERY, CONTRAST-ENHANCED MRI, 20-YEAR FOLLOW-UP, RADIOFREQUENCY ABLATION, THERMOMETRY, THERAPY, US, FEASIBILITY, MAMMOGRAPHY, TISSUE, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
ISSN: 0031-9155
(Publisher version, Peer reviewed)