Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
Bhoo-Pathy, Nirmala; Peeters, Petra H M; Uiterwaal, Cuno S P M; Bueno-de-Mesquita, H. Bas; Bulgiba, Awang M.; Bech, Hammer H.; Overvad, Kim; Tjønneland, Anne; Olsen, Anja; Clavel-Chapelon, Françoise; Fagherazzi, Guy; Perquier, Florence; Teucher, Birgit; Kaaks, Rudolf; Schütze, Madlen; Boeing, Heiner; Lagiou, Pagona; Orfanos, Philippos; Trichopoulou, Antonia; Agnoli, Claudia; Mattiello, Amalia; Palli, Domenico; Tumino, Rosario; Sacerdote, Carlotta; Van Duijnhoven, Franzel J B; Braaten, Tonje; Lund, Eiliv; Skeie, Guri; Redondo, María Luisa; Buckland, Genevieve; Pérez, Sánchez J S; Chirlaque, Maria Dolores; Ardanaz, Eva; Amiano, Pilar; Wirfält, Elisabet; Wallström, Peter; Johansson, Ingegerd; Nilsson, Maria M.; Khaw, Kay Tee; Wareham, Nick; Allen, Naomi E.; Key, Timothy J.; Rinaldi, Sabina; Romieu, Isabelle; Gallo, Valentina; Riboli, Elio; Van Gils, Carla H.
(2015) Breast Cancer Research, volume 17, issue 1
(Article)
Abstract
Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer. Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC)
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Study, completed a dietary questionnaire from 1992 to 2000, and were followed-up until 2010 for incidence of breast cancer. Hazard ratios (HR) of breast cancer by country-specific, as well as cohort-wide categories of beverage intake were estimated. Results: During an average follow-up of 11 years, 1064 premenopausal, and 9134 postmenopausal breast cancers were diagnosed. Caffeinated coffee intake was associated with lower risk of postmenopausal breast cancer: adjusted HR = 0.90, 95% confidence interval (CI): 0.82 to 0.98, for high versus low consumption; P trend = 0.029. While there was no significant effect modification by hormone receptor status (P = 0.711), linear trend for lower risk of breast cancer with increasing caffeinated coffee intake was clearest for estrogen and progesterone receptor negative (ER-PR-), postmenopausal breast cancer (P = 0.008). For every 100 ml increase in caffeinated coffee intake, the risk of ER-PR- breast cancer was lower by 4% (adjusted HR: 0.96, 95% CI: 0.93 to 1.00). Non-consumers of decaffeinated coffee had lower risk of postmenopausal breast cancer (adjusted HR = 0.89; 95% CI: 0.80 to 0.99) compared to low consumers, without evidence of dose-response relationship (P trend = 0.128). Exclusive decaffeinated coffee consumption was not related to postmenopausal breast cancer risk, compared to any decaffeinated-low caffeinated intake (adjusted HR = 0.97; 95% CI: 0.82 to 1.14), or to no intake of any coffee (HR: 0.96; 95%: 0.82 to 1.14). Caffeinated and decaffeinated coffee were not associated with premenopausal breast cancer. Tea intake was neither associated with pre- nor post-menopausal breast cancer. Conclusions: Higher caffeinated coffee intake may be associated with lower risk of postmenopausal breast cancer. Decaffeinated coffee intake does not seem to be associated with breast cancer.
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Keywords: SEX-HORMONE CONCENTRATIONS, CAFFEINE CONSUMPTION, DECAFFEINATED COFFEE, WOMEN, PREMENOPAUSAL, METAANALYSIS, CALIBRATION, POPULATION, VALIDITY, HEALTH, Cancer Research, Oncology
ISSN: 1465-5411
Publisher: BioMed Central
(Peer reviewed)