Insulin-like growth factor I and risk of epithelial invasive ovarian cancer by tumour characteristics: Results from the EPIC cohort
Ose, J.; Fortner, R. T.; Schock, H.; Peeters, P. H.; Onland-Moret, N. C.; Bueno-De-Mesquita, H. B.; Weiderpass, E.; Gram, I. T.; Overvad, K.; Tjonneland, A.; Dossus, L.; Fournier, A.; Baglietto, L.; Trichopoulou, A.; Benetou, V.; Trichopoulos, D.; Boeing, H.; Masala, G.; Krogh, V.; Matiello, A.; Tumino, R.; Popovic, M.; Obón-Santacana, M.; Larrañaga, N.; Ardanaz, E.; Sánchez, M. J.; Menéndez, V.; Chirlaque, M. D.; Travis, R. C.; Khaw, K. T.; Brändstedt, J.; Idahl, A.; Lundin, E.; Rinaldi, S.; Kuhn, E.; Romieu, I.; Gunter, M. J.; Merritt, M. A.; Riboli, E.; Kaaks, R.
(2015) British Journal of Cancer, volume 112, issue 1, pp. 162 - 166
(Article)
Abstract
Background: Prospective studies on insulin-like growth factor I (IGF-I) and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest risk associations vary by tumour characteristics. Methods: We conducted a nested case-control study in the European Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate IGF-I concentrations and EOC risk by
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tumour characteristics (n=565 cases). Multivariable conditional logistic regression models were used to estimate associations. Results: We observed no association between IGF-I and EOC overall or by tumour characteristics. Conclusions: In the largest prospective study to date was no association between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations may not influence EOC risk.
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Keywords: carcinogenesis, dualistic pathway, histological subtypes, IGF-I, ovarian cancer, type I/type II, Cancer Research, Oncology, General Medicine
ISSN: 0007-0920
Publisher: Nature Publishing Group
(Peer reviewed)
