Dietary intake of carotenoids and risk of type 2 diabetes
Sluijs, I.; Cadier, E.; Beulens, J. W J; van der A, D. L.; Spijkerman, A. M W; van der Schouw, Y. T.
(2015) NMCD : Nutrition metabolism and cardiovascular diseases, volume 25, issue 4, pp. 376 - 381
(Article)
Abstract
Background and aims: Carotenoids may reduce diabetes risk, due to their antioxidant properties. However, the association between dietary carotenoids intake and type 2 diabetes risk is still unclear. Therefore, the objective of this study was to examine whether higher dietary carotenoid intakes associate with reduced type 2 diabetes risk. Methods
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and results: Data from 37,846 participants of the European Prospective Investigation into Cancer and Nutrition-Netherlands study were analyzed. Dietary intakes of beta-carotene, alpha-carotene, beta-cryptoxanthin, lycopene, lutein & zeaxanthin and the sum of these carotenoids were assessed using a validated food frequency questionnaire. Incident type 2 diabetes was mainly self-reported, and verified against general practitioner information. Mean +/- SD total carotenoid intake was 10 + 4 mg/day. During a mean +SD follow-up of 10 + 2years, 915 incident cases of type 2 diabetes were ascertained. After adjustment for age, sex, diabetes risk factors, dietary intake, waist circumference and BMI, higher beta-carotene intakes associated inversely with diabetes risk [Hazard Ratio quartile 4 versus quartile 1 (HRQ4): 0.78 (95%CI:0.64,0.95), P-linear trend 0.01]. For alpha-carotene, a borderline significant reduced risk was observed, with a HRQ4 of 0.85 (95%CI:0.70,1.03), and P-linear trend 0.05. beta-cryptoxanthin, lycopene, lutein & zeaxanthin, and the sum of all carotenoids did not associate with diabetes risk. Conclusions: This study shows that diets high in beta-carotene and alpha-carotene are associated with reduced type 2 diabetes in generally healthy men and women. (C) 2015 Elsevier B.V. All rights reserved.
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Keywords: Carotenoids, Cohort study, Diet, Type 2 diabetes, beta-carotene, alpha-carotene, RANDOMIZED CONTROLLED-TRIAL, BETA-CAROTENE, CARDIOVASCULAR-DISEASE, OXIDATIVE STRESS, COHORT PROFILE, MALE SMOKERS, HUMAN HEALTH, EPIC-NL, ANTIOXIDANTS, VALIDITY, Medicine (miscellaneous), Nutrition and Dietetics, Endocrinology, Diabetes and Metabolism, Cardiology and Cardiovascular Medicine, Journal Article, Research Support, Non-U.S. Gov't
ISSN: 0939-4753
Publisher: Elsevier
(Peer reviewed)