Upregulation of Class I MHC on Neuroblastoma Cells By NK Cell Exposure for Enhanced CTL Reactivity

Abstract

Neuroblastoma is the most common solid tumor in pediatric patients, with a clear unmet need as survival rates are <20% for stage IV disease. As adjuvant immunotherapy is considered to have additional anti-tumor activity we aim to increase cytotoxic T lymphocyte (CTL)-mediated immune surveillance in neuroblastoma patients by administration of a dendritic cell-based vaccine. Neuroblastoma has developed mechanisms to circumvent CTL recognition; therefore it is our aim to find clinical strategies to make neuroblastoma susceptible for CTL killing