Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide

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Linear synthesis and immunological properties of a fully synthetic vaccine candidate containing a sialylated MUC1 glycopeptide
 
Thompson, Pamela; Lakshminarayanan, Vani; Supekar, Nitin T.; Bradley, Judy M.; Cohen, Peter A.; Wolfert, Margreet A.; Gendler, Sandra J.; Boons, Geert Jan
(2015) Chemical Communications, volume 51, issue 50, pp. 10214 - 10217
(Article)
Abstract
A strategy for the linear synthesis of a sialylated glycolipopeptide cancer vaccine candidate has been developed using a strategically designed sialyl-Tn building block and microwave-assisted solid-phase peptide synthesis. The glycolipopeptide elicited potent humoral and cellular immune responses. T-cells primed by such a vaccine candidate could be restimulated by tumor-associated MUC1.
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Keywords: Taverne, General Chemistry, Catalysis, Ceramics and Composites, Electronic, Optical and Magnetic Materials, Surfaces, Coatings and Films, Materials Chemistry, Metals and Alloys
DOI: https://doi.org/10.1039/c5cc02199e
ISSN: 1359-7345
Publisher: Royal Society of Chemistry
(Peer reviewed)
 
 
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