Lung cancer risk among bricklayers in a pooled analysis of case-control studies.
Consonni, Dario; De Matteis, Sara; Pesatori, Angela C; Bertazzi, Pier Alberto; Olsson, Ann C; Kromhout, Hans; Peters, Susan; Vermeulen, Roel Ch; Pesch, Beate; Brüning, Thomas; Kendzia, Benjamin; Behrens, Thomas; Stücker, Isabelle; Guida, Florence; Wichmann, Heinz-Erich; Brüske, Irene; Landi, Maria Teresa; Caporaso, Neil E; Gustavsson, Per; Plato, Nils; Tse, Lap Ah; Yu, Ignatius Tak-Sun; Jöckel, Karl-Heinz; Ahrens, Wolfgang; Pohlabeln, Hermann; Merletti, Franco; Richiardi, Lorenzo; Simonato, Lorenzo; Forastiere, Francesco; Siemiatycki, Jack; Parent, Marie-Élise; Tardón, Adonina; Boffetta, Paolo; Zaridze, David; Chen, Ying; Field, John K; 't Mannetje, Andrea; Pearce, Neil; McLaughlin, John; Demers, Paul; Lissowska, Jolanta; Szeszenia-Dabrowska, Neonila; Bencko, Vladimir; Foretova, Lenka; Janout, Vladimir; Rudnai, Peter; Fabiánová, Eleonóra; Stanescu Dumitru, Rodica; Bueno-de-Mesquita, Bas; Schüz, Joachim; Straif, Kurt
(2015) International Journal of Cancer, volume 136, issue 2, pp. 360 - 371
(Article)
Abstract
Bricklayers may be exposed to several lung carcinogens, including crystalline silica and asbestos. Previous studies that analysed lung cancer risk among these workers had several study design limitations. We examined lung cancer risk among bricklayers within SYNERGY, a large international pooled analysis of case-control studies on lung cancer and the
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joint effects of occupational carcinogens. For men ever employed as bricklayers we estimated odds ratios (OR) and 95% confidence intervals (CI) adjusted for study centre, age, lifetime smoking history, and employment in occupations with exposures to known or suspected lung carcinogens. Among 15,608 cases and 18,531 controls, there were 695 cases and 469 controls who had ever worked as bricklayers (OR: 1.47; 95% CI: 1.28-1.68). In studies using population controls the OR was 1.55 (95% CI: 1.32-1.81, 540/349 cases/controls), while it was 1.24 (95% CI: 0.93-1.64, 155/120 cases/controls) in hospital-based studies. There was a clear positive trend with length of employment (p
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Keywords: german social accident insurance, national cancer institute of, fp 271, epidemiology, occupational, occupational health, online version of this, research and guzzo-src chair, dguv, control studies, case, canadian institutes for health, canadian cancer society, canada, bricklayers, be found in the, article, additional supporting information may, grant sponsors, in environment and cancer, lung neoplasms, grant sponsor, grant number, Gustavsson, Occupational medicine, 2014, Plato, Taverne
ISSN: 0020-7136
Publisher: Wiley-Liss Inc.
(Peer reviewed)