Candida parapsilosis molecular epidemiology and host defense

Abstract

Aim of the study is to obtain more insight in the molecular epidemiology and the innate immunity against Candida parapsilosis. Knowledge on how C. parapsilosis spread and invade the host can lead to define adequate preventive measures to curb the rise in incidence of these infections. As important contribution to the innate immunity the role of opsonins and polymorphonuclear neutrophils in the pathogenesis of C. parapsilosis were studied. The epidemiology was studied using fingerprinting techniques. A novel genome DNA micro-array was developed for better understanding properties of C. parapsilosis.