Similar occurrence of febrile episodes reported in non-atopic children at three to five years of age after prebiotics supplemented infant formula
Van Stuijvenberg, Margriet; Stam, José; Grüber, Christoph; Mosca, Fabio; Arslanoglu, Sertac; Chirico, Gaetano; Braegger, Christian P.; Riedler, Josef; Boehm, Günther; Sauer, Pieter J J; Van Der Schaaf, Caroline; Wahn, Ulrich; Wauer, Juliane; Parasher, Kirn; Wust, Madeleine; Lawnitzak, Ingrid; Trentmann, Marion; Schulz, Gabi; Hamelmann, Eckard; Paschke-Goossens, Susanne; Bellach, Johanna; Ahrens, Birgit; Roggero, Paola; Piemontese, Pasqua; Gianni, Maria Lorella; Morlacchi, Laura; Moro, Guido; Rizzardi, Silvia; Rigotti, Elisa; Tandoi, Laura; Coppola, Michela; Bühr, Patrick; Friedt, Michael; Koller, Rebecca; Rogler, Daniela; Rueger, Vanessa; Macheiner, Margret; Tyma, Christine; Antonella, Gasparoni; Elena, Garzoli; Chiara, Offer; Vania, Spinoni; Graziella, Iacono; Maria, Stellini; Van Der Mooren, Jan; Yavuz, Yalcin; Garssen, Johan; Knippels, Leon; Knol, Jan; Amor, Kaouther Ben; Jelinek, Jürgen; Stahl, Bernd; König, Esther; Frings, Anja; Wittke, Anja; Zens, Yvonne; Cremers, Stephanie; Friedrichs, Kathrin; Gerloff, Janine; Bruno, Gemma; Fischer, Ayako
(2015) PLoS One, volume 10, issue 6
(Article)
Abstract
This is a follow up study of a multicenter randomised placebo-controlled trial in seven centres in five West European countries. The RCT assessed the effect of infant formula supplemented with a mixture of prebiotics (with neutral short-chain and long-chain oligosaccharides and pectin-derived acidic oligosaccharides) during infancy in term-born children (n=1130).
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In the follow-up study 672 children (60% of the study population) participated: 232 (56%) from the prebiotics group (PG), 243 (58%) from the control group (CG), and 197 (66%) from the non-randomised breast-fed group (BG). The primary outcome was the occurrence of febrile episodes at three to five years of age prospectively documented by the parents: in the PG 1.17 (interquartile range 0.50-2.08) episodes per year versus 1.20 (0.52-2.57) in the CG; and 1.48 (0.65-2.60) in the BG. This specific prebiotics mixture given during infancy in healthy non-atopic subjects does not decrease febrile episodes and therefore seems not to prevent infection between their third and fifth birthday.
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Keywords: General Agricultural and Biological Sciences, General Biochemistry,Genetics and Molecular Biology, General Medicine
ISSN: 1932-6203
Publisher: Public Library of Science
(Peer reviewed)