Abstract
BRCC36 is a Zn<sup>2+</sup>-dependent deubiquitinating enzyme (DUB) that hydrolyzes lysine-63-linked ubiquitin chains as part of distinct macromolecular complexes that participate in either interferon signaling or DNA-damage recognition. The MPN<sup>+</sup> domain protein BRCC36 associates with pseudo DUB MPN<sup>-</sup> proteins KIAA0157 or Abraxas, which are essential for BRCC36 enzymatic activity. To understand
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