Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping

Jordan, Nan Yeun; Mimpen, Jolet Y.; van den Bogaard, Willie J. M.; Flesch, Frits M.; van de Meent, Michiel H. M.; Torano, Javier Sastre

doi:https://doi.org/10.1016/j.jchromb.2015.05.020

Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping

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Analysis of caffeine and paraxanthine in human saliva with ultra-high-performance liquid chromatography for CYP1A2 phenotyping

Jordan, Nan Yeun; Mimpen, Jolet Y.; van den Bogaard, Willie J. M.; Flesch, Frits M.; van de Meent, Michiel H. M.; Torano, Javier Sastre

(2015) Journal of chromatography. B, volume 995, pp. 70 - 73

(Article)

Abstract

Cytochrome P450 1A2 (CYP1A2) plays an important role in drug metabolism. Caffeine (CAF) is converted into paraxanthine (PX) by this enzyme and is used as a xenobiotic substrate to determine the CYP1A2 phenotype in humans. A method for the quantification of CAF and PX in saliva was developed using liquid-liquid ... read more

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Keywords: Caffeine, Paraxanthine, CYP1A2, Phenotyping, Saliva, UHPLC, IN-VIVO, PLASMA, THEOPHYLLINE, METABOLITES, CYP2E1, RATIO, DRUG

DOI: https://doi.org/10.1016/j.jchromb.2015.05.020

ISSN: 1570-0232

Publisher: Elsevier

(Peer reviewed)

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