Factor VIII interacts with the endocytic receptor low-density lipoprotein receptor-related protein 1 via an extended surface comprising "hot-spot" lysine residues

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Factor VIII interacts with the endocytic receptor low-density lipoprotein receptor-related protein 1 via an extended surface comprising "hot-spot" lysine residues
 
Van Den Biggelaar, Maartje; Madsen, Jesper J.; Faber, Johan H.; Zuurveld, Marleen G.; Van Der Zwaan, Carmen; Olsen, Ole H.; Stennicke, Henning R.; Mertens, Koen; Meijer, Alexander B.
(2015) Journal of Biological Chemistry, volume 290, issue 27, pp. 16463 - 16476
(Article)
Abstract
Background: It is unclear how the LDL receptor family binds large protein ligands. Results: HDX and lysine scanning identified factor (F)VIII regions and specific lysine residues binding low-density lipoprotein receptor-related protein 1 (LRP1). Conclusion: FVIII-LRP1 interaction involves multiple "hot-spot" lysine residues in the A3C1 domains. Significance: Our study sheds light ... read more
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Keywords: Taverne, Biochemistry, Cell Biology, Molecular Biology
DOI: https://doi.org/10.1074/jbc.M115.650911
ISSN: 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
(Peer reviewed)
 
 
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