The bovine T cell receptor alpha/delta locus contains over 400 V genes and encodes V genes without CDR2
Reinink, Peter; van Rhijn, I.
(2009) Immunogenetics, volume 61, issue 7, pp. 541 - 549
(Article)
Abstract
Alphabeta T cells and gammadelta T cells perform nonoverlapping immune functions. In mammalian species with a high percentage of very diverse gammadelta T cells, like ruminants and pigs, it is often assumed that alphabeta T cells are less diverse than gammadelta T cells. Based on the bovine genome, we have
... read more
created a map of the bovine TRA/TRD locus and show that, in cattle, in addition to the anticipated >100 TRDV genes, there are also >300 TRAV or TRAV/DV genes. Among the V genes in the TRA/TRD locus, there are several genes that lack a CDR2 and are functionally rearranged and transcribed and, in some cases, have an extended CDR1. The number of bovine V genes is a multiple of the number in mice and humans and may encode T cell receptors that use a novel way of interacting with antigen.
show less
Download/Full Text
Embargo until January 01 2050
Keywords: Amino Acid Sequence, Animals, Cattle, Chromosome Mapping, Complementarity Determining Regions, Databases, Genetic, Gene Rearrangement, T-Lymphocyte, Genes, T-Cell Receptor alpha, Genes, T-Cell Receptor delta, Humans, Immunogenetic Phenomena, Mice, Molecular Sequence Data, Phylogeny, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Sequence Homology, Amino Acid, Species Specificity
ISSN: 0093-7711
Publisher: Springer Verlag
(Peer reviewed)
See more statistics about this item