Body mass index in young school-age children in relation to organochlorine compounds in early life: a prospective study
Hoyer, B. B.; Ramlau-Hansen, C. H.; Henriksen, T. B.; Pedersen, H. S.; Goralczyk, K.; Zviezdai, V.; Jonsson, B. A. G.; Heederik, D.; Lenters, V.; Vermeulen, R.; Bonde, J. P.; Toft, G.
(2014) International Journal of Obesity, volume 38, issue 7, pp. 919 - 925
(Article)
Abstract
OBJECTIVE: To investigate the association between maternal pregnancy and estimated postnatal serum concentrations of the organochlorines 2,2', 4,4', 5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl) ethylene (p, p'-DDE) and body mass index (BMI) z-scores in 5- to 9-year-old children. METHODS: Maternal sera from the INUENDO birth cohort (2002-2004) comprising mother-child pairs (N =
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1109) from Greenland, Warsaw (Poland), and Kharkiv (Ukraine) were analysed for CB-153 and p, p'-DDE, using gas chromatography-mass-spectrometry, and were grouped into tertiles for statistical analyses. A toxicokinetic model was used to estimate the first 12 months cumulative exposure to the compounds. Associations between these compounds and child age-and sex-specific BMI z-scores were calculated at follow-up (2010-2012), using multiple linear regression analysis. RESULTS: No clear associations between pregnancy CB-153 and p, p'-DDE and child BMI were observed (the pooled differences in BMI z-score (95% confidence interval) comparing 3rd tertile to 1st tertile were -0.07 (-0.32 to 0.18) and -0.10 (-0.30 to 0.10) kg m(-2), respectively). For postnatal CB-153 and p, p'-DDE and BMI, the overall differences in BMI z-score comparing 3rd tertile to 1st tertile were 0.12 (-0.15 to 0.39) and -0.03 (-0.20 to 0.27) k gm(-2), respectively. CONCLUSIONS: This follow-up study of Greenlandic, Polish and Ukrainian populations showed no clear association between pregnancy and postnatal exposure to p, p'-DDE and CB-153 and BMI at the age of 5-9 years.
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Keywords: body mass index, child, cohort study, dichlorodiphenyl dichloroethylene (DDE), polychlorinated biphenyls (PCBs), prenatal exposure delayed effects, POLYCHLORINATED-BIPHENYLS PCBS, PRENATAL EXPOSURE, CHILDHOOD GROWTH, THYROID-HORMONE, BIRTH COHORT, BREAST-MILK, 2 CITIES, OVERWEIGHT, OBESITY, DDT, Coronacrisis-Taverne
ISSN: 0307-0565
Publisher: Nature Publishing Group
(Peer reviewed)
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