Abstract
Recombinant TNF-related apoptosis-inducing
ligand (TRAIL) is considered a powerful and selective
inducer of tumor cell death. We hypothesize that TRAIL’s
potential as anticancer agent can be enhanced further by
promoting its accumulation in tumor tissue. For this purpose,
we developed TRAIL complexes that bind to
angiogenic endothelial cells. We employed an avidin–
biotin pretargeting approach, in which
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