The neuro-immune axis: Prospect for novel treatments for mental disorders
Kraneveld, Aletta D.; de Theije, Caroline G.M.; van Heesch, Floor; Borre, Yuliya; de Kivit, Sander; Olivier, Berend; Korte, Mechiel; Garssen, Johan
(2014) Basic & Clinical Pharmacology & Toxicology, volume 114, issue 1, pp. 128 - 136
(Article)
Abstract
Disturbed bidirectional pathways between the (central) nervous system and immune system have been implicated in various mental disorders, including depressive and neurodevelopmental disorders. In this minireview, the role of the neuro-immune axis and its targetability in relation to major depression and autism spectrum disorder will be discussed. All together, the
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management of these and possibly other multi-factorial mental disorders needs a new and integrated therapeutic approach. Pharmacologically bioactive molecules as well as medical nutrition targeting the (gut)-immune-brain axis could be such an approach. © 2013 Nordic Pharmacological Society.
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Keywords: acetylcholine, adrenalin, alpha interferon, antibody, brain derived neurotrophic factor, bungarotoxin receptor, corticosteroid, immunomodulating agent, interleukin 1beta, interleukin 6, nerve growth factor, neuropeptide, neurotransmitter, nicotinic receptor, noradrenalin, serotonin transporter, toll like receptor 4, transforming growth factor beta, tumor necrosis factor alpha, astrocyte, autism, B lymphocyte, blood brain barrier, central nervous system, clinical trial (topic), cognitive defect, cytokine production, dendritic cell, efferent nerve, eosinophil, food aversion, granulocyte, human, hypothalamus hypophysis adrenal system, inflammatory disease, innate immunity, intestine flora, intracellular signaling, leukocyte, lymphocyte, macrophage, major depression, mast cell, meta analysis (topic), microglia, mononuclear phagocyte, nervous system inflammation, neuroimmunology, neurologic disease, nonhuman, nucleus accumbens, pain receptor, prefrontal cortex, priority journal, review, sensory nerve, social interaction, T lymphocyte
ISSN: 1742-7835
Publisher: Blackwell Publishing Ltd
(Peer reviewed)