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Population Pharmacokinetics and Target Attainment of Allopurinol and Oxypurinol Before, During, and After Cardiac Surgery with Cardiopulmonary Bypass in Neonates with Critical Congenital Heart Disease

Chu, Wan-Yu; Nijman, Maaike; Stegeman, Raymond; Breur, Johannes M P J; Jansen, Nicolaas J G; Nijman, Joppe; van Loon, Kim; Koomen, Erik; Allegaert, Karel; Benders, Manon J N L; Dorlo, Thomas P C; Huitema, Alwin D R; CRUCIAL trial consortium (Adis, 2024-08)

BACKGROUND: The CRUCIAL trial (NCT04217421) is investigating the effect of postnatal and perioperative administration of allopurinol on postoperative brain injury in neonates with critical congenital heart disease (CCHD) ...
Machine-Learning Analysis of mRNA: An Application to Inflammatory Bowel Disease

Rojas-Velazquez, David; Kidwai, Sarah; De Vries, Lucienne; Tozser, Peter; Valencia-Rosado, Luis Oswaldo; Garssen, Johan; Tonda, Alberto; Lopez-Rincon, Alejandro (IEEE Computer Society Press, 2024)

Inflammatory Bowel Disease (IBD), that includes Crohn's disease (CD) and Ulcerative Colitis (UC), is a global health concern due to the increasing number of cases. Diagnosing IBD is a challenging task due to a considerable ...
Hoogste tijd voor onderzoek naar het afbouwen van onderhoudsbehandeling voor bipolaire stoornissen

Dols, Annemiek; Mathijssen, Henk; Kupka, Ralph; Regeer, Eline (Uitgeverij Boom, 2024)

Achtergrond Bij bipolaire stoornissen wordt meestal een indicatie gesteld voor preventieve onderhoudsbehandeling, maar wetenschappelijk bewijs hiervoor is beperkt. Doel Beargumenteren dat onderzoek naar afbouwen van ...
A systematic literature review of time series methods applied to epidemic prediction

Batoure Bamana, Apollinaire; Shafiee Kamalabad, Mahdi; Oberski, Daniel L. (Elsevier, 2024)

While time series are extensively utilized in economics, finance and meteorology, their application in epidemics has been comparatively limited. To facilitate a comprehensive research endeavor on this matter, we deemed it ...
Early evaluation of the effectiveness and cost-effectiveness of ctDNA-guided selection for adjuvant chemotherapy in stage II colon cancer

Kramer, Astrid; Greuter, Marjolein J E; Schraa, Suzanna J; Vink, Geraldine R; Phallen, Jillian; Velculescu, Victor E; Meijer, Gerrit A; van den Broek, Daan; Koopman, Miriam; Roodhart, Jeanine M L; Fijneman, Remond J A; Retèl, Valesca P; Coupé, Veerle M H (SAGE Publications Inc., 2024-01-01)

BACKGROUND: Current patient selection for adjuvant chemotherapy (ACT) after curative surgery for stage II colon cancer (CC) is suboptimal, causing overtreatment of high-risk patients and undertreatment of low-risk patients. ...
Limited predictive value of the gut microbiome and metabolome for response to biological therapy in inflammatory bowel disease

Prins, Femke M; Hidding, Iwan J; Klaassen, Marjolein A Y; Collij, Valerie; Schultheiss, Johannes P D; Uniken Venema, Werna T C; Bangma, Amber; Aardema, Jurne B; Jansen, Bernadien H; Mares, Wout G N; Witteman, Ben J M; Festen, Eleonora A M; Dijkstra, Gerard; Visschedijk, Marijn C; Fidder, Herma H; Vich Vila, Arnau; Oldenburg, Bas; Gacesa, Ranko; Weersma, Rinse K (Landes Bioscience, 2024-08-21)

Emerging evidence suggests the gut microbiome's potential in predicting response to biologic treatments in patients with inflammatory bowel disease (IBD). In this prospective study, we aimed to predict treatment response ...
Mechanism and regulation of cargo entry into the Commander endosomal recycling pathway

Butkovič, Rebeka; Walker, Alexander P; Healy, Michael D; McNally, Kerrie E; Liu, Meihan; Veenendaal, Tineke; Kato, Kohji; Liv, Nalan; Klumperman, Judith; Collins, Brett M; Cullen, Peter J (Nature Publishing Group, 2024-12)

Commander is a multiprotein complex that orchestrates endosomal recycling of integral cargo proteins and is essential for normal development. While the structure of this complex has recently been described, how cargo ...
Inoperable chronic thromboembolic pulmonary hypertension: Evolution of prognosis over 10 years of new emerging therapies

Staal, Diederik P; Hendriks, Paul M; van Thor, Mitch C J; van de Groep, Liza D; van den Toorn, Leon M; Mulder, Berend-Jan M; Chandoesing, Prewesh P; Kauling, Robert M; Boerman, Sanne; van den Bosch, Annemien E; Mager, Johannes J; Boomars, Karin A; Post, Martijn C (John Wiley & Sons Inc., 2024-07)

Therapies for inoperable chronic thromboembolic pulmonary hypertension (CTEPH) include balloon pulmonary angioplasty (BPA) and PH-specific medical therapy. This study compares survival and its predictors before and after ...
White matter integrity in hospitalized COVID-19 patients is not associated with short- and long-term clinical outcomes

van Lith, Theresa J; Li, Hao; van der Wijk, Marte W; Wijers, Naomi T; Sluis, Wouter M; Wermer, Marieke J H; de Leeuw, Frank-Erik; Meijer, Frederick J A; Tuladhar, Anil M (Frontiers Media S. A., 2024-08-08)

Objectives: SARS-CoV-2 infection is associated with a decline in functional outcomes; many patients experience persistent symptoms, while the underlying pathophysiology remains unclear. This study investigated white matter ...
Leveraging FHIR in Federated Learning Environments: A Data Harmonization Framework for Cohort Studies

Cadavid, Héctor; Arends, Bauke (IOS Press, 2024-08-22)

MyDigiTwin is a scientific initiative for the development of a platform for the early detection and prevention of cardiovascular diseases. This platform, which is supported by prediction models trained in a federated fashion ...
Practice variation in home care nursing: mapping potential explanations through a scoping review of the literature

Brabers, A E M; Meijer, M A M; Groenewegen, P P; Bleijenberg, N; Zwakhalen, S; de Jong, J D (2024-08-21)

Needs assessment is the starting point of good home care as it determines which care is necessary, based on the needs of patients, their personal situation, and social context. There are indications that practice variation ...
Evaluation of risk prediction models to select lung cancer screening participants in Europe: a prospective cohort consortium analysis

Feng, Xiaoshuang; Goodley, Patrick; Alcala, Karine; Guida, Florence; Kaaks, Rudolf; Vermeulen, Roel; Downward, George S; Bonet, Catalina; Colorado-Yohar, Sandra M; Albanes, Demetrius; Weinstein, Stephanie J; Goldberg, Marcel; Zins, Marie; Relton, Caroline; Langhammer, Arnulf; Skogholt, Anne Heidi; Johansson, Mattias; Robbins, Hilary A (Elsevier, 2024-09)

BACKGROUND: Lung cancer risk prediction models might efficiently identify individuals who should be offered lung cancer screening. However, their performance has not been comprehensively evaluated in Europe. We aimed to ...
A cross-sectional study in 18 patients with typical and mild forms of nemaline myopathy in the Netherlands

van Kleef, Esmee S B; van de Camp, Sanne A J H; Groothuis, Jan T; Erasmus, Corrie E; Gaytant, Michael A; Vosse, Bettine A H; de Weerd, Willemien; Verschuuren-Bemelmans, Corien C; Medici-Van den Herik, Evita G; Wallgren-Pettersson, Carina; Küsters, Benno; Schouten, Meyke; van Engelen, Baziel G M; Ottenheijm, Coen A C; Doorduin, Jonne; Voermans, Nicol C (Elsevier Limited, 2024-10)

Nemaline myopathy (NM) is a congenital myopathy with generalised muscle weakness, most pronounced in neck flexor, bulbar and respiratory muscles. The aim of this cross-sectional study was to assess the Dutch NM patient ...
On the design and development of a handheld electrocardiogram device in a clinical setting

Zepeda-Echavarria, Alejandra; Ratering Arntz, Niek C M; Westra, Albert H; van Schelven, Leonard J; Euwe, Froukje E; Noordmans, Herke Jan; Vessies, Melle; van de Leur, Rutger R; Hassink, Rutger J; Wildbergh, Thierry X; van der Zee, Rien; Doevendans, Pieter A; van Es, René; Jaspers, Joris E N (Frontiers Media S. A., 2024-08-09)

Cardiovascular diseases (CVDs) are a global burden that requires attention. For the detection and diagnosis of CVDs, the 12-lead ECG is a key tool. With technological advancements, ECG devices are becoming smaller and ...
Heterozygous missense CSF1R variants hamper in vitro CD34+-derived dendritic cell generation but not in vivo dendritic cell development

Beerepoot, Shanice; Wolf, Nicole I; van der Knaap, Marjo S; Nierkens, Stefan; Plantinga, Maud (Elsevier Limited, 2024-10)

Colony stimulating factor 1 receptor (CSF1R) is an essential receptor for both colony stimulating factor 1 (CSF1) and interleukin (IL) 34 signaling expressed on monocyte precursors and myeloid cells, including monocytes, ...
Cerebroplacental ratio in low-risk pregnancies: the RATIO37 trial

Meijerink, Lotte; Terstappen, Fieke; Depmann, Martine; Bekker, Mireille; Lely, Titia (Elsevier, 2024-08-24)
Omega-3 supplementation changes the physical properties of leukocytes but not erythrocytes in healthy individuals: An exploratory trial

Schuchardt, Jan Philipp; Kräter, Martin; Schlögel, Maximilian; Guck, Jochen; van Oirschot-Hermans, Brigitte A.; Bos, Jennifer; van Wijk, Richard; Tintle, Nathan L.; Westra, Jason; Kerlikowsky, Felix; Hahn, Andreas; Harris, William S. (Churchill Livingstone, 2024-03)

n3-PUFA impact health in several ways, including cardiovascular protection and anti-inflammatory effects, but the underlying mechanisms are not fully understood. In this exploratory study involving 31 healthy subjects, we ...
From diagnosis to dialogue – reconsidering the DSM as a conversation piece in mental health care: a hypothesis and theory

Veldmeijer, Lars; Terlouw, Gijs; van Os, Jim; te Meerman, Sanne; van ‘t Veer, Job; Boonstra, Nynke (Frontiers Research Foundation, 2024-08-06)

The Diagnostic and Statistical Manual of Mental Disorders, abbreviated as the DSM, is one of mental health care’s most commonly used classification systems. While the DSM has been successful in establishing a shared language ...
Editorial: The ethics of speech ownership in the context of neural control of augmented assistive communication

Freudenburg, Zachary; Berezutskaya, Julia; Herbert, Cornelia (Frontiers Research Foundation, 2024-08-06)
MR-OCTAVIUS 4D with 1500 MR and 1600 MR arrays is suitable for plan QA in a 1.5 T MRI-linac

Gorobets, Viktoriia; Vries, Wilfred de; Brand, Nicole; Foppen, Thomas; Wopereis, André J.M.; Woodings, Simon (IOP Publishing Ltd., 2024-09-07)

To ensure the accuracy of radiation delivery to patients in a 1.5 T MRI-linac, the implementation of quality assurance (QA) devices compatible with MR technology is essential. The OCTAVIUS 4D MR, made by PTW (Freiburg, ...

Now showing items 4981-5000 of 40729